ArticleBMC pulmonary medicine2013
Obesity increases eosinophil activity in asthmatic children and adolescents.
Article in BMC pulmonary medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.The Journal of allergy and clinical immunology · 2018Trial
- Inflammatory Dysregulation, Asthma, and Obesity in Children: What is the Relationship?Journal of inflammation research · 2026Review
- Obesity-driven airway eosinophilia and neutrophilia in asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025Review
- Obesity: Next game changer of allergic airway diseases?Clinical and translational medicine · 2025Review
- Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma.The Journal of allergy and clinical immunology · 2025Article
- Serum leptin and adiponectin function as indicators of allergic sensitization in pediatric adenotonsillar hypertrophy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Article
- Body Weight and Allergic Asthma: A Narrative Review.Journal of clinical medicine · 2024Review
- Mechanistic Links Between Obesity and Airway Pathobiology Inform Therapies for Obesity-Related Asthma.Paediatric drugs · 2023Review
- Article
- Obesity-related asthma and its relationship with microbiota.Frontiers in cellular and infection microbiology · 2023Review
- Complex interplay of gut microbiota between obesity and asthma in children.Frontiers in microbiology · 2023Review
- Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022Review
- Th1/Th2 cytokines profile in overweight/obese young adults and their correlation with airways inflammation.Journal of Taibah University Medical Sciences · 2022Article
- Possible Role of Leptin in Atopic Dermatitis: A Literature Review.Biomolecules · 2021Review
- Adiponectin and Asthma: Knowns, Unknowns and Controversies.International journal of molecular sciences · 2021Review
- Contribution of systemic and airway immune responses to pediatric obesity-related asthma.Paediatric respiratory reviews · 2021Review
- Unraveling the connection between eosinophils and obesity.Journal of leukocyte biology · 2020Review
- Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor.Sensors (Basel, Switzerland) · 2020Review
- The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction.International journal of endocrinology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA clear relationship between asthma and obesity has been reported, but the mechanisms remain unclear. The aim of this study was to evaluate the influence of obesity on eosinophil activity (chemotaxis and adhesion) in asthmatic children and adolescents compared with cells from healthy volunteers.
methodsAsthmatic obese (AO), asthmatic non-obese (ANO), non-asthmatic obese (NAO) and non-asthmatic non-obese (NANO) individuals were included in the present study. The chemotaxis of eosinophils after stimulation with eotaxin (300 ng/ml), platelet-activating factor (10 μM; PAF) and RANTES (100 ng/ml) was performed using a microchemotaxis chamber. The eosinophil peroxidase activity was measured to determine the adhesion activity of eosinophils cultivated on fibronectin-coated plates. The serum leptin, adiponectin, TNF-α and IgE levels were quantified using ELISA assays.
resultsThe serum IgE levels and eosinophil counts were significantly higher in asthmatic (obese and non-obese) individuals compared with non-asthmatic individuals (obese and non-obese). Spontaneous eosinophil chemotaxis was greater in the AO group compared with either the ANO or NANO groups. The activation of eosinophils using eotaxin and PAF increased eosinophil chemotaxis in the AO group. RANTES treatment increased eosinophil chemotaxis in the NAO group compared with the NANO or ANO groups. The activation of eosinophils using eotaxin significantly increased eosinophil adhesion in the AO group compared with other groups. The serum leptin and TNF-α levels were higher in obese subjects (asthmatic and non-asthmatic), whereas the levels of adiponectin did not significantly differ among these groups.
conclusionThis study is the first to show increased eosinophilic activity (chemotaxis and adhesion) associated with high serum leptin and TNF-α levels in atopic asthmatic obese children and adolescents compared with non-obese healthy volunteers.
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Registered trials
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