ArticleBMC pharmacology & toxicology2013
Effects of packaging and storage conditions on the quality of amoxicillin-clavulanic acid - an analysis of Cambodian samples.
Article in BMC pharmacology & toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Characterizing Medicine Quality by Active Pharmaceutical Ingredient Levels: A Systematic Review and Meta-Analysis across Low- and Middle-Income Countries.The American journal of tropical medicine and hygiene · 2022Pooled it
- Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis.JAMA network open · 2018Pooled it
- Comparative Assessment of the Pharmaceutical Quality of Amoxicillin Capsules Marketed in Authorized and an Unregulated Point of Sale in Mexican Market.Therapeutic innovation & regulatory science · 2026Article
- Quality evaluation of cephalexin, cefuroxime, and ceftriaxone medicines marketed in Addis Ababa city, Ethiopia with three tier level approach and anti-microbial assays.BMC pharmacology & toxicology · 2025Article
- Article
- Comparative bioavailability study of two oral formulations of amoxicillin-clavulanic acid in healthy dogs.BMC veterinary research · 2025Article
- Redefining Counterfeit Medicines and Updating the Legal Framework to Address Falsified Medicines: A Qualitative Policy Review.Acta medica Philippina · 2025Article
- Circulation of COVID-19-Related Medicines on Japanese Websites during the COVID-19 Pandemic and Their Quality and Authenticity.The American journal of tropical medicine and hygiene · 2024Article
- Quality of veterinary anthelmintic drugs marketed in Gondar Zones, North West Ethiopia; presence of poor-quality medicines.Heliyon · 2023Article
- A random survey of the prevalence of falsified and substandard antibiotics in the Lao PDR.The Journal of antimicrobial chemotherapy · 2022Article
- A comprehensive analysis of selected medicines collected from private drug outlets of Dhaka city, Bangladesh in a simple random survey.Scientific reports · 2022Article
- From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium.Drug delivery and translational research · 2021Article
- Small-scale dissolution test screening tool to select potentially substandard and falsified (SF) medicines requiring full pharmacopoeial analysis.Scientific reports · 2021Article
- Patient safety and public health concerns: poor dissolution rate of pioglitazone tablets obtained from China, Myanmar and internet sites.BMC pharmacology & toxicology · 2021Article
- Clarification of the internal structure and factors of poor dissolution of substandard roxithromycin tablets by near-infrared chemical imaging.International journal of pharmaceutics · 2021Article
- Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries.BMJ open · 2020Article
- A cross-sectional analysis of falsified, counterfeit and substandard medicines in a low-middle income country.BMC public health · 2020Article
- Substandard and Falsified Medicines in Myanmar.Pharmacy (Basel, Switzerland) · 2020Article
- A Cross-Sectional Investigation of the Quality of Selected Medicines for Noncommunicable Diseases in Private Community Drug Outlets in Cambodia during 2011-2013.The American journal of tropical medicine and hygiene · 2019Article
- An Investigation into the Quality of Medicines in Yangon, Myanmar.Pharmacy (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of substandard and degraded medicines is a major public health problem in developing countries such as Cambodia. A collaborative study was conducted to evaluate the quality of amoxicillin-clavulanic acid preparations under tropical conditions in a developing country.
methodsAmoxicillin-clavulanic acid tablets were obtained from outlets in Cambodia. Packaging condition, printed information, and other sources of information were examined. The samples were tested for quantity, content uniformity, and dissolution. Authenticity was verified with manufacturers and regulatory authorities.
resultsA total of 59 samples were collected from 48 medicine outlets. Most (93.2%) of the samples were of foreign origin. Using predetermined acceptance criteria, 12 samples (20.3%) were non-compliant. Eight (13.6%), 10 (16.9%), and 20 (33.9%) samples failed quantity, content uniformity, and dissolution tests, respectively. Samples that violated our observational acceptance criteria were significantly more likely to fail the quality tests (Fisher's exact test, p < 0.05).
conclusionsImproper packaging and storage conditions may reduce the quality of amoxicillin-clavulanic acid preparations at community pharmacies. Strict quality control measures are urgently needed to maintain the quality of amoxicillin-clavulanic acid in tropical countries.
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