Trial reportJournal of the American Geriatrics Society2013
Independent and combined effects of physical activity and weight loss on inflammatory biomarkers in overweight and obese older adults.
Trial report in Journal of the American Geriatrics Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The effect of dietary weight-loss interventions on the inflammatory markers interleukin-6 and TNF-alpha in adults with obesity: A systematic review and meta-analysis of randomized controlled clinical trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Effect of exercise on abdominal obesity and inflammatory response in the older adults: a systematic review and meta-analysis of randomized controlled trials.Frontiers in sports and active living · 2025Pooled it
- The impact of exercise and dietary interventions on circulating leptin and adiponectin in individuals who are overweight and those with obesity: A systematic review and meta-analysis.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- A Meta-Analysis of the Effects of Different Exercise Modes on Inflammatory Response in the Elderly.International journal of environmental research and public health · 2022Pooled it
- The Effects of Exercise on Appetite in Older Adults: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis.PloS one · 2017Pooled it
- Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials.PloS one · 2015Pooled it
- Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial.Experimental gerontology · 2021Trial
- Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.GeroScience · 2019Trial
- Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes.European journal of applied physiology · 2017Trial
- Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.Journal of the American Geriatrics Society · 2017Trial
- Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men.European journal of applied physiology · 2016Trial
- A long-term intensive lifestyle intervention and physical function: the look AHEAD Movement and Memory Study.Obesity (Silver Spring, Md.) · 2015Trial
- Effect of an 18-month physical activity and weight loss intervention on body composition in overweight and obese older adults.Obesity (Silver Spring, Md.) · 2014Trial
- Effects of a community-based weight loss intervention on adipose tissue circulating factors.Diabetes & metabolic syndromeTrial
- Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Eight weeks of moderate aerobic exercise on body composition and markers of inflammation and oxidative stress in middle-aged obese females.Journal of exercise rehabilitation · 2025Article
- Physical Exercise, a Potential Non-Pharmacological Intervention for Attenuating Neuroinflammation and Cognitive Decline in Alzheimer's Disease Patients.International journal of molecular sciences · 2022Review
- Causal associations of obesity related anthropometric indicators and body compositions with knee and hip arthritis: A large-scale genetic correlation study.Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesTo determine the independent effect of long-term physical activity (PA) and the combined effects of long-term PA and weight loss (WL) on inflammation in overweight and obese older adults.
designEighteen-month randomized, controlled trial.
settingThe community infrastructure of cooperative extension centers.
participantsOverweight and obese (body mass index >28.0 kg/m(2) ) community-dwelling men and women aged 60 to 79 at risk for cardiovascular disease (CVD).
interventionPhysical activity + weight loss (PA + WL) (n = 98), PA only (n = 97), or successful aging (SA) health education (n = 93) intervention. MEASUREMENTS: Biomarkers of inflammation (adiponectin, leptin, high-sensitivity interleukin (hsIL)-6, IL-6sR, IL-8, and soluble tumor necrosis factor receptor 1) were measured at baseline and 6 and 18 months.
resultsAfter adjustment for baseline biomarker, wave, sex, and visit, leptin and hsIL-6 showed a significant intervention effect. Specifically, leptin was significantly lower in the PA + WL group (21.3 ng/mL, 95% confidence interval (CI) = 19.7-22.9 ng/mL) than in the PA (29.3 ng/mL, 95% CI = 26.9-31.8 ng/mL) or SA (30.3 ng/mL, 95% CI = 27.9-32.8 ng/mL) group (both P < .001), and hsIL-6 was significantly lower in the PA + WL group (2.1 pg/mL, 95% CI = 1.9-2.3 pg/mL) than in the PA (2.5 pg/mL, 95% CI = 2.3-2.7 pg/mL) or SA (2.4 pg/mL, 95% CI = 2.2-2.6 pg/mL) group (P = .02).
conclusionAddition of dietary-induced WL to PA reduced leptin and hsIL-6 more than PA alone and more than a SA intervention in older adults at risk for CVD. Results suggest that WL, rather than increased PA, is the lifestyle factor primarily responsible for improvement in the inflammatory profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.