ArticleFEBS open bio2013
Zinc-binding and structural properties of the histidine-rich loop of Arabidopsis thaliana vacuolar membrane zinc transporter MTP1.
Article in FEBS open bio, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 38 citations in OpenAlex.
- Metal-sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT1.The Biochemical journal · 2025Article
- Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms.International journal of molecular sciences · 2024Review
- Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of ZnNature communications · 2023Article
- Resolving the zinc binding capacity of honey bee vitellogenin and locating its putative binding sites.Insect molecular biology · 2022Article
- Review
- Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides.Inorganic chemistry · 2022Article
- Identification and functional analysis of cation-efflux transporter 1 from Brassica juncea L.BMC plant biology · 2022Article
- Metal transport mechanism of the cation diffusion facilitator (CDF) protein family - a structural perspective on human CDF (ZnT)-related diseases.RSC chemical biology · 2021Review
- The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport.The Biochemical journal · 2019Article
- Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter.PLoS computational biology · 2018Article
- Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants.Scientific reports · 2018Article
- Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity.PLoS pathogens · 2015Article
- Current understanding of ZIP and ZnT zinc transporters in human health and diseases.Cellular and molecular life sciences : CMLS · 2014Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
The vacuolar Zn(2+)/H(+) antiporter of Arabidopsis thaliana, AtMTP1, has a cytosolic histidine-rich loop (His-loop). We characterized the structures and Zn(2+)-binding properties of the His-loop and other domains. Circular dichroism analyses revealed that the His-loop partly consists of a polyproline type II structure and that its conformational change is induced by Zn(2+) as well as the C-terminal domain. Isothermal titration calorimetry of the His-loop revealed a binding number of four Zn(2+) per molecule. Numbers of Ni and Co associated with the His-loop were approximately one ion per molecule and the thermodynamic parameters of the association with these ions were different from that of Zn(2+). These results suggest the involvement of the His-loop in sensing cytosolic Zn(2+) and in the regulation of zinc transport activity through Zn(2+)-induced structural change.
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