ArticleFEBS open bio2013
Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan.
Article in FEBS open bio, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 81 citations in OpenAlex.
- Vitamin BNature communications · 2026Article
- Vitamin B12 induces memory of predation through vitellogenin provisioning.Nature communications · 2026Article
- Lifespan-Extending Endogenous Metabolites.Aging cell · 2026Review
- Vitamin BResearch square · 2025Article
- A simple, fast and inexpensive approach using E. coli to detect and estimate vitamin B12 content in microbial extracts.Biology open · 2025Article
- Article
- Understanding the factors regulating host-microbiome interactions usingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- ThemBio · 2024Article
- Geroprotective potential of microbiome modulators in the Caenorhabditis elegans model.GeroScience · 2024Review
- Vitamin BNature cell biology · 2024Article
- Potential Anti-Alzheimer Properties of Mogrosides in Vitamin B12-DeficientMolecules (Basel, Switzerland) · 2023Article
- Domestication and microbiome succession may drive pathogen spillover.Frontiers in microbiology · 2023Article
- Microbiota-derived metabolites in regulating the development and physiology ofFrontiers in microbiology · 2023Review
- Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans.Aging cell · 2022Article
- Dietary-derived vitamin B12 protects Caenorhabditis elegans from thiol-reducing agents.BMC biology · 2022Article
- Dietary vitamin B12 regulates chemosensory receptor gene expression via the MEF2 transcription factor in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- Anti-Obesity Efficacy ofInternational journal of molecular sciences · 2022Article
- Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span.Aging cell · 2022Article
- Dityrosine Crosslinking of Collagen and Amyloid-β Peptides Is Formed by Vitamin BInternational journal of molecular sciences · 2021Article
- Effects of Vitamin BAntioxidants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin B12 (B12) deficiency has been linked to developmental disorders, metabolic abnormalities, and neuropathy; however, the mechanisms involved remain poorly understood. Caenorhabditis elegans grown under B12-deficient conditions for five generations develop severe B12 deficiency associated with various phenotypes that include decreased egg-laying capacity (infertility), prolonged life cycle (growth retardation), and reduced lifespan. These phenotypes resemble the consequences of B12 deficiency in mammals, and can be induced in C. elegans in only 15 days. Thus, C. elegans is a suitable animal model for studying the biological processes induced by vitamin deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.