ArticleFEBS open bio2013
Structure and function of a bacterial Fasciclin I Domain Protein elucidates function of related cell adhesion proteins such as TGFBIp and periostin.
Article in FEBS open bio, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Periostin in joint physiology and pathology: multiple roles from mechanisms to clinical perspectives.Histochemistry and cell biology · 2026Review
- Crystal structures of Fsc1, a novel autophagy factor that mediates autophagosome-vacuole fusion in fission yeast.Acta crystallographica. Section D, Structural biology · 2026Article
- Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future.Irish veterinary journal · 2023Review
- Metabolic handoffs between multiple symbionts may benefit the deep-sea bathymodioline mussels.ISME communications · 2023Article
- Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP.Communications biology · 2023Article
- Cas9/gRNA-Mediated Mutations inInternational journal of molecular sciences · 2022Article
- Serum periostin level is not sufficient to serve as a clinically applicable biomarker of osteoarthritis.BMC musculoskeletal disorders · 2022Article
- System-Level Analysis of Transcriptional and Translational Regulatory Elements inFrontiers in bioengineering and biotechnology · 2022Article
- Article
- Pathological Roles and Clinical Usefulness of Periostin in Type 2 Inflammation and Pulmonary Fibrosis.Biomolecules · 2021Review
- Review
- Transcriptomics reveal core activities of the plant growth-promoting bacteriumMicrobial genomics · 2020Article
- The adherence-associated Fdp fasciclin I domain protein of the biohydrogen producerInternational journal of hydrogen energy · 2020Article
- The Cytoskeleton and Its Role in Determining Cellulose Microfibril Angle in Secondary Cell Walls of Woody Tree Species.Plants (Basel, Switzerland) · 2020Review
- Fasciclin-Like Arabinogalactan-Protein 16 (FLA16) Is Required for Stem Development inFrontiers in plant science · 2020Article
- Genome analysis of Rubritalea profundi SAORIC-165Journal of microbiology (Seoul, Korea) · 2019Article
- Characterization of the protein fraction of the extracellular polymeric substances of three anaerobic granular sludges.AMB Express · 2019Article
- Fascinating Fasciclins: A Surprisingly Widespread Family of Proteins that Mediate Interactions between the Cell Exterior and the Cell Surface.International journal of molecular sciences · 2018Review
- A speculation on the tandem fasciclin 1 repeat of FLA4 proteins in angiosperms.Plant signaling & behavior · 2018Article
- Fasciclin-calcareous corpuscle binary complex mediated protein-protein interactions in Taenia solium metacestode.Parasites & vectors · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fasciclin I (FAS1) domains have important roles in cell adhesion, which are not understood despite many structural and functional studies. Examples of FAS1 domain proteins include TGFBIp (βig-h3) and periostin, which function in angiogenesis and development of cornea and bone, and are also highly expressed in cancer tissues. Here we report the structure of a single-domain bacterial fasciclin I protein, Fdp, in the free-living photosynthetic bacterium Rhodobacter sphaeroides, and show that it confers cell adhesion properties in vivo. A binding site is identified which includes the most highly conserved region and is adjacent to the N-terminus. By mapping this onto eukaryotic homologues, which all contain tandem FAS1 domains, it is concluded that the interaction site is normally buried in the dimer interface. This explains why corneal dystrophy mutations are concentrated in the C-terminal domain of TGFBIp and suggests new therapeutic approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.