ArticleFEBS open bio2012
Transcription of N- and O-linked mannosyltransferase genes is modulated by the pacC gene in the human dermatophyte Trichophyton rubrum.
Article in FEBS open bio, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Alternative Splicing Analysis Revealed That the Transcription Factor PacC Shapes the Virulence of the DermatophyteInternational journal of molecular sciences · 2026Article
- Unveiling the Role of StuA in Transcription Regulation in Trichophyton rubrum: From Global Regulation Dynamics to the pH-Responsive Program Control.Mycopathologia · 2025Article
- Dermatophytosis in context of Trichophyton rubrum: host defense mechanisms, virulence factors, and treatment innovations.Molecular biology reports · 2025Review
- A Dual-Plasmid-Based CRISPR/Cas9-Mediated Strategy Enables Targeted Editing of pH Regulatory GeneJournal of fungi (Basel, Switzerland) · 2022Article
- Relevance of Nutrient-Sensing in the Pathogenesis ofFrontiers in fungal biology · 2022Article
- State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms.Journal of fungi (Basel, Switzerland) · 2021Review
- Metabolomic analysis of Trichophyton rubrum and Microsporum canis during keratin degradation.Scientific reports · 2021Article
- The PAC-3 transcription factor critically regulates phenotype-associated genes in Neurospora crassa.Genetics and molecular biology · 2020Article
- HacA Governs Virulence Traits and Adaptive Stress Responses inFrontiers in microbiology · 2020Article
- Pathogenesis of Dermatophytosis: Sensing the Host Tissue.Mycopathologia · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fungi, ambient pH sensing involves the activation of the Pal/PacC signalling pathway. In the dermatophyte Trichophyton rubrum, pH-dependent secretion of keratinases, which are major virulence determinants, is affected by disruption of the pacC gene. Here, the transcription profiling of the genes coding for N- and O-linked mannosyltransferases, enzymes involved in protein glycosylation, was evaluated in T. rubrum in response to disruption of the pacC gene and growth in keratin, glucose, and glucose plus glycine. We show that transcription of these mannosyltransferase genes is affected by nutrients at acidic pH and by PacC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.