ArticlePregnancy hypertension2013
Prepregnancy Vascular Dysfunction in Women who Subsequently Develop Hypertension During Pregnancy.
Article in Pregnancy hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Impaired Flow-Mediated Dilation Before, During, and After Preeclampsia: A Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2016Pooled it
- Prepregnancy physiology and subsequent preterm preeclampsia.American journal of obstetrics and gynecology · 2025Article
- Differences between macrovascular and microvascular functions in pregnant women with chronic hypertension or preeclampsia: new insights into maternal vascular health.Frontiers in physiology · 2025Article
- Subclinical Metabolic and Cardiovascular Factors and Brain White Matter Microstructural Integrity in Young Women.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Placental syndromes and maternal cardiovascular health.Clinical science (London, England : 1979) · 2023Review
- Corin-The Early Marker of Preeclampsia in Pregestational Diabetes Mellitus.Journal of clinical medicine · 2022Article
- Augmentation index and pulse wave velocity in normotensive versus preeclamptic pregnancies: a prospective case-control study using a new oscillometric method.Annals of medicine · 2022Article
- Placental Maternal Vascular Malperfusion is Associated with Prepregnancy and Early Pregnancy Maternal Cardiovascular and Thrombotic Profiles.Reproductive medicine (Basel, Switzerland) · 2022Article
- Maternal Low Volume Circulation Relates to Normotensive and Preeclamptic Fetal Growth Restriction.Frontiers in medicine · 2022Review
- Association of pre-pregnancy subclinical insulin resistance with cardiac dysfunction in healthy nulliparous women.Pregnancy hypertension · 2021Observational
- Measures of adiposity correlate with renal filtration in young nulliparous women: An observational cohort study.Obesity science & practice · 2020Article
- Adiposity, but not Obesity, Is Associated With Arterial Stiffness in Young Nulliparous Women.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Effect of Pregnancy Interval on Second Pregnancy Blood Pressure Following Prior Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Differences in cardiovascular function comparing prior preeclamptics with nulliparous controls.Pregnancy hypertension · 2016Article
- Pregnancy induces persistent changes in vascular compliance in primiparous women.American journal of obstetrics and gynecology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate vascular dysfunction using both physiologic measures and biochemical markers, longitudinally, prior to and during pregnancy, in nulliparous women who had uncomplicated pregnancies compared to those who developed complicated hypertension during pregnancy.
methodsTwenty healthy nulliparous women were studied during the follicular phase and in early (EP) and late (LP) pregnancy. All had singleton conceptions and delivered at term, seventeen with uncomplicated pregnancies (NP) and three who developed complicated hypertension (HP) after the LP evaluation. We compared prepregnancy, EP and LP pulse wave velocity (PWV) and soluble vascular cell adhesion molecule (sVCAM-1) between the NP and HP groups. PWV was measured using ultrasound and simultaneous echocardiogram tracing then calculated as the estimated distance divided by interval between EKG r-wave peak and peak brachial artery flow. SVCAM-1 was measured using a commercially available kit. Data are means ± SE, significance accepted as p < 0.05.
resultsThe NP group had significantly lower prepregnant PWV (NP: 2.66 ± 0.06 m/s, HP: 3.00 ± 0.04, p=.02), but PWV was not different at the EP or LP time points. SVCAM-1 was significantly lower prior to pregnancy and during EP and LP in the NP group (Prepregnancy: NP: 712 ± 32 ng/mL, HP: 1058 ± 107, p < .001; EP: NP: 695 ± 31 ng/mL, HP: 924 ± 52, p = .004; LP: NP: 663 ± 25 ng/mL, HP: 946 ± 36, p < .001).
conclusionsPWV and sVCAM-1 may be important prepregnancy discriminators useful in assessing risk for preeclampsia prior to pregnancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.