ArticleFrontiers in immunology2013
Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation.
Article in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- Evaluation of procalcitonin and C-reactive protein levels in children with autism spectrum disorder and attention deficit hyperactivity disorder.International journal of developmental disabilities · 2025Article
- Hematopoietic stem cell transplantation ameliorates maternal diabetes-mediated gastrointestinal symptoms and autism-like behavior in mouse offspring.Annals of the New York Academy of Sciences · 2022Article
- In Reply.Stem cells translational medicine · 2021Article
- Maternal Diabetes Induces Immune Dysfunction in Autistic Offspring Through Oxidative Stress in Hematopoietic Stem Cells.Frontiers in psychiatry · 2020Article
- Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Stem cell therapy in autism: recent insights.Stem cells and cloning : advances and applications · 2018Review
- Redox proteomic identification of carbonylated proteins in autism plasma: insight into oxidative stress and its related biomarkers in autism.Clinical proteomics · 2017Article
- The use of stem cells to study autism spectrum disorder.The Yale journal of biology and medicine · 2015Review
- Commentary: The Impact of Neuroimmune Alterations in Autism Spectrum Disorder.Frontiers in psychiatry · 2015Article
- Mesenchymal stem cells in treating autism: Novel insights.World journal of stem cells · 2014Review
- The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.Journal of neuroinflammation · 2014Article
- Immune dysregulation in autism spectrum disorder.European journal of pediatrics · 2014Review
- Epigenetic findings in autism: new perspectives for therapy.International journal of environmental research and public health · 2013Review
- Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review.Cell transplantationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism and autism spectrum disorders (ASDs) are heterogeneous, severe neuro-developmental disorders with core symptoms of dysfunctions in social interactions and communication skills, restricted interests, repetitive - stereotypic verbal and non-verbal behaviors. Biomolecular evidence points to complex gene-environmental interactions in ASDs. Several biochemical processes are associated with ASDs: oxidative stress (including endoplasmic reticulum stress), decreased methylation capacity, limited production of glutathione; mitochondrial dysfunction, intestinal dysbiosis, increased toxic metal burden, and various immune abnormalities. The known immunological disorders include: T-lymphocyte populations and function, gene expression changes in monocytes, several autoimmune-related findings, high levels of N-acetylgalactosaminidase (which precludes macrophage activation), and primary immune deficiencies. These immunological observations may result in minicolumn structural changes in the brain, as well as, abnormal immune mediation of synaptic functions. Equally, these immune dysregulations serve as the rationale for immune-directed interventions such as hematopoietic stem cells (HSCs), which are pivotal in controlling chronic inflammation and in the restoration of immunological balance. These properties make them intriguing potential agents for ASD treatments. This prospective review will focus on the current state-of-the-art knowledge and challenges intrinsic in the application of HSCs for ASD-related immunological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.