ArticleJournal of Korean medical science2013
Prevalence and risk factors of low bone mineral density in Korean HIV-infected patients: impact of abacavir and zidovudine.
Article in Journal of Korean medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- TDF and quantitative ultrasound bone quality in African patients on second line ART, ANRS 12169 2LADY sub-study.PloS one · 2017Trial
- Article
- The effect of anti-retroviral therapy on fracture healing : an in vivo animal model.Bone & joint research · 2022Article
- Assessment of Human Immunodeficiency Virus Care Continuum in Korea using the National Health Insurance System Data.Infection & chemotherapy · 2021Article
- Low bone mass in people living with HIV on long-term anti-retroviral therapy: A single center study in Uganda.PloS one · 2021Article
- HIV Infection and Bone Abnormalities.The open orthopaedics journal · 2017Article
- Bone health and HIV in resource-limited settings: a scoping review.Current opinion in HIV and AIDS · 2016Article
- Bone alterations associated with HIV.Current HIV/AIDS reports · 2014Article
- Non-traumatic Unilateral Femur Neck Fracture in a Human Immunodeficiency Virus-Positive Septuagenarian Indian Male: A Unique Case Report.Journal of orthopaedic case reportsArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Low bone mineral density (BMD) is common in HIV-infected patients. We aimed to describe the prevalence of low BMD and risk factors in Korean HIV-infected patients and to assess the effects of antiretroviral therapy (ART) on BMD. We retrospectively evaluated 224 HIV infected-patients. The prevalence of osteopenia and osteoporosis were 41.5% and 12.9%. These were much higher in 53 patients aged 50 yr and older (52.8% and 34.0%). Older age, lower body mass index, and ART > 3 months were independent risk factors for low BMD. Osteoporosis was more prevalent in patients on the abacavir-based regimen for < 1 yr than ≥ 1 yr; however, it was more prevalent in patients on the zidovudine-based regimen for ≥ 1 yr than < 1 yr (P = 0.017). Osteoporosis in patients on the abacavir-based regimen was more common in the spine than in the femur (P = 0.01). Given such a high prevalence of low BMD, close monitoring of BMD for HIV-infected patients on ART is required. The different prevalence of osteoporosis over time and affected areas between two regimens suggest they may play roles in different mechanisms in bone loss.
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