ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
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- B Cells Influence Encephalitogenic T Cell Frequency to Myelin Oligodendrocyte Glycoprotein (MOG)38-49 during Full-length MOG Protein-Induced Demyelinating Disease.ImmunoHorizons · 2024Article
- Persistent B Cell-Derived MHC Class II Signaling Is Required for the Optimal Maintenance of Tissue-Resident Helper T Cells.ImmunoHorizons · 2024Article
- MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4Oncoimmunology · 2024Article
- Article
- Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance.The Journal of experimental medicine · 2022Article
- Article
- Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load.The Journal of allergy and clinical immunology · 2021Article
- Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE.International journal of molecular sciences · 2021Article
- Functional Role of B Cells in Atherosclerosis.Cells · 2021Review
- cDC1 prime and are licensed by CD4Nature · 2020Article
- B Cell-Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression.ImmunoHorizons · 2019Article
- Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2018Review
- MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis.Immunology · 2018Article
- Role of B cells in TThe Journal of allergy and clinical immunology · 2018Article
- Article
- Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo.PloS one · 2017Article
- Amelioration of EAE by a cryptic epitope of myelin oligodendrocyte glycoprotein.Journal of neuroimmunology · 2016Article
- B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
The activation, differentiation, and subsequent effector functions of CD4 T cells depend on interactions with a multitude of MHC class II (MHCII)-expressing APCs. To evaluate the individual contribution of various APCs to CD4 T cell function, we have designed a new murine tool for selective in vivo expression of MHCII in subsets of APCs. Conditional expression of MHCII in B cells was achieved using a cre-loxP approach. After i.v. or s.c. priming, partial proliferation and activation of CD4 T cells was observed in mice expressing MHCII only by B cells. Restricting MHCII expression to B cells constrained secondary CD4 T cell responses in vivo, as demonstrated in a CD4 T cell-dependent model of autoimmunity, experimental autoimmune encephalomyelitis. These results highlight the limitations of B cell Ag presentation during initiation and propagation of CD4 T cell function in vivo using a novel system to study individual APCs by the conditional expression of MHCII.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.