Evidence map›Paper›PMID 23771989›Full record

Trial reportAnnals of the rheumatic diseases2014

Weight loss and achievement of minimal disease activity in patients with psoriatic arthritis starting treatment with tumour necrosis factor α blockers.

Matteo Nicola Dario Di Minno, Rosario Peluso, Salvatore Iervolino, Anna Russolillo, Roberta Lupoli, Raffaele Scarpa, CaRRDs Study Group

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of the rheumatic diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05590247 (Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis), which is not on this map. Cited by 112 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 13 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05590247 nacompletednot on this mapstarted 2022, after this paper: background citation

Role of Intermittent Fasting on Disease Severity and Quality of Life in Psoriasis and Psoriatic Arthritis

TypeinterventionalSponsorOhio State UniversityRan2022 to 2025Enrolled60ConditionsPsoriasis, Psoriatic ArthritisArmsIntermittent Fasting Diet
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 13 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Pooled it
  2. Brazilian Society of Rheumatology 2020 guidelines for psoriatic arthritis.Advances in rheumatology (London, England) · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Lifestyle changes for treating psoriasis.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Guideline
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Trial
  16. Dietetic intervention in psoriatic arthritis: the DIETA trial.Advances in rheumatology (London, England) · 2022
    Trial
  17. Trial
  18. Lifestyle Modification for the Management of Psoriatic Arthritis.American journal of lifestyle medicine · 2026
    Review
  19. Review
  20. Review

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matteo Nicola Dario Di MinnoRegional Reference Center for Coagulation Disorders, , Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Rosario Peluso
Salvatore Iervolino
Anna Russolillo
Roberta Lupoli
Raffaele Scarpa
CaRRDs Study Group
Federico II University Hospital · ITFondazione Salvatore Maugeri · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate prospectively the effect of weight loss on the achievement of minimal disease activity (MDA) in overweight/obese patients with psoriatic arthritis (PsA) starting treatment with tumour necrosis factor α (TNFα) blockers.

methodsAmong subjects with PsA starting treatment with TNFα blockers, 138 overweight/obese patients received a concomitant dietary intervention (69 a hypocaloric diet (HD) and 69 a free-managed diet (FD)). Changes in metabolic variables were measured and a complete clinical rheumatological evaluation was made in all patients at baseline and after a 6-month follow-up to define the achievement of MDA.

results126 subjects completed the study. MDA was more often achieved by HD than by FD subjects (HR=1.85, 95% CI 1.019 to 3.345, p=0.043). A diet was successful (≥5% weight loss) in 74 (58.7%) patients. Regardless of the type of diet, after 6 months of treatment with TNFα blockers, ≥5% of weight loss was a predictor of the achievement of MDA (OR=4.20, 95% CI 1.82 to 9.66, p<0.001). For increasing weight-loss categories (<5%, 5-10%, >10%), MDA was achieved by 23.1%, 44.8% and 59.5%, respectively. A higher rate of MDA achievement was found in subjects with 5-10% (OR=3.75, 95% CI 1.36 to 10.36, p=0.011) and in those with >10% (OR=6.67, 95% CI 2.41 to 18.41, p<0.001) weight loss in comparison with those with <5% weight loss.

conclusionsRegardless of the type of diet, a successful weight loss (≥5% from baseline values) is associated with a higher rate of achievement of MDA in overweight/obese patients with PsA who start treatment with TNFα blockers.

Indexed as

Caloric RestrictionAdalimumabAdultAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntirheumatic AgentsArthritis, PsoriaticDrug Therapy, CombinationEtanerceptFemaleHumansImmunoglobulin GInfliximabMaleMethotrexateMiddle AgedAdalimumabAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntirheumatic AgentsEtanerceptImmunoglobulin GInfliximabMethotrexateReceptors, Tumor Necrosis FactorTumor Necrosis Factor-alphaDisease ActivityPsoriatic ArthritisTNF-alpha

Identifiers

PMID23771989
PMCPMC4033114
OpenAlexW2106668113

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.