ArticleThe journal of physiological sciences : JPS2013
Effect of systemic α1-adrenergic receptor blockade on central blood pressure response during exercise.
Article in The journal of physiological sciences : JPS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Effect of Very Low-Intensity Resistance Exercise on Aortic-Brachial Blood Pressure Disparity in Young Men.American journal of hypertension · 2026Trial
- Attenuated aortic-cerebral pulsatile transmission with posture-related increases in stroke volume in healthy young adults.European journal of applied physiology · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- A critical assessment of sympathetic restraint in submaximal exercise: Implications for integrated cardiovascular circuit control in exercise.Experimental physiology · 2025Review
- Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Attenuated pulsatile transition to the cerebral vasculature during high-intensity interval exercise in young healthy men.Experimental physiology · 2023Article
- Dynamic resistance exercise-induced pressor response does not alter hypercapnia-induced cerebral vasodilation in young adults.European journal of applied physiology · 2023Article
- Effect of Aquatic Exercise Training on Aortic Hemodynamics in Middle-Aged and Elderly Adults.Frontiers in cardiovascular medicine · 2021Article
- No influence of lower leg heating on central arterial pulse pressure in young men.The journal of physiological sciences : JPS · 2015Article
- Influence of single bout of aerobic exercise on aortic pulse pressure.European journal of applied physiology · 2015Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The aortic pulse pressure (PP), which consists mainly of the incident wave and the reflected wave, has emerged as an important property of systemic blood vessels underlying the pathophysiology of cardiovascular disease. To determine the role of sympathetic nerve activity on the aortic PP response during dynamic exercise, we evaluated aortic hemodynamics during the right-leg knee-extension (40 and 60 % of maximal voluntary contraction) in six young adults with and without the systemic α1-adrenergic receptor blockade using prazosin (1 mg/20 kg body weight). The use of prazosin attenuated the exercise-induced increase in aortic PP (P < 0.05) but not in radial arterial PP. The amplitude of the reflected waves (via augmentation index) significantly decreased with the exercise and decreased more with the use of prazosin. These results suggest that during dynamic exercise the α1-adrenergic-mediated vasoconstrictor tone of the peripheral resistance vessels is manifestly involved in the magnitude of the reflected wave and the modulation of the aortic PP responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.