SynthesisNeurosurgical review2014
Functional outcome and postoperative complications after the microsurgical removal of large vestibular schwannomas via the retrosigmoid approach: a meta-analysis.
Synthesis in Neurosurgical review, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Surgical management for large vestibular schwannomas: a systematic review, meta-analysis, and consensus statement on behalf of the EANS skull base section.Acta neurochirurgica · 2020Pooled it
- Morphological Heterogeneity of Large (Koos Grade 4) Vestibular Schwannomas: Surgical Consequences and Predictors of Facial Nerve Outcome.Journal of clinical medicine · 2026Article
- N-Cadherin Dynamically Regulates Schwannoma Migration and Represents a Novel Therapeutic Target in NF2-Related Schwannomatosis.Research square · 2026Article
- Diffusion MRI of the facial-vestibulocochlear nerve complex: a prospective clinical validation study.European radiology · 2023Article
- Hypervascularized Large Vestibular Schwannomas: Single-Center Experience in a Series of Forty Cases.World neurosurgery: X · 2023Article
- Microsurgery for vestibular schwannoma: analysis of short-term clinical outcome.Chinese neurosurgical journal · 2022Article
- Value of intraoperative monitoring of the trigeminal nerve in detection of a superiorly displaced facial nerve during surgery for large vestibular schwannomas.Neurosurgical review · 2022Article
- The Bigger the Better? Analysis of Surgical Complications and Outcome of the Retrosigmoid Approach in 449 Oncological Cases.Frontiers in oncology · 2022Article
- Koos grade IV vestibular schwannomas: considerations on a consecutive series of 60 cases-searching for the balance between preservation of function and maximal tumor removal.Neurosurgical review · 2021Article
- Microsurgery for Vestibular Schwannoma via Retrosigmoid Transmeatal Approach with Intraoperative Monitoring Techniques.Balkan medical journal · 2021Article
- Comparison between retrosigmoid and translabyrinthine approaches for large vestibular schwannoma: focus on cerebellar injury and morbidities.Neurosurgical review · 2021Article
- TcMEP threshold change is superior to A-train detection when predicting facial nerve outcome in CPA tumour surgery.Acta neurochirurgica · 2020Article
- Continuous dynamic mapping to avoid accidental injury of the facial nerve during surgery for large vestibular schwannomas.Neurosurgical review · 2020Article
- Microsurgical Treatment and Follow-Up of KOOS Grade IV Vestibular Schwannoma: Therapeutic Concept and Future Perspective.Frontiers in oncology · 2020Article
- Facial nerve function and hearing after microsurgical removal of sporadic vestibular schwannomas in a population-based cohort.Acta neurochirurgica · 2020Article
- Summary and consensus in 7th International Conference on acoustic neuroma: An update for the management of sporadic acoustic neuromas.World journal of otorhinolaryngology - head and neck surgery · 2016Article
- Staging in giant vestibular Schwannoma surgery.Journal of neurosciences in rural practice · 2014Article
- Gross-total versus near-total resection of large vestibular schwannomas. An institutional experience.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For large (≥30 mm) or giant (≥40 mm) vestibular schwannomas (VSs) for which microsurgical removal is the main treatment option, complete tumour resection and the preservation of acceptable facial nerve function can be safely and successfully achieved via the retrosigmoid approach. We performed a meta-analysis to provide a reliable estimate of functional outcome and postoperative complications for patients treated surgically for large VSs. We conducted a comprehensive search in Pubmed, Embase and the Chinese National Knowledge Infrastructure (CNKI) databases to identify publications that included only patients in whom the VSs were >3.0 cm in maximal diameter and microsurgically removed by a retrosigmoid approach. Pooled estimates of proportions with corresponding 95 % confidence intervals were calculated using the Freeman-Tukey double arcsine transformation. This meta-analysis revealed that the pooled proportion of gross total resections was 79.1 % (95 % CI, 64.2-90.8 %; I (2) = 95.4 %). By combining microsurgical techniques with continuous electrophysiological monitoring, the anatomical preservation of the facial nerve at the end of surgery was achieved in 88.8 % (95 % CI, 83.6-93.2 %; I (2) = 76.1 %) of the patients. The pooled proportion of good postoperative facial nerve function (House-Brackmann (HB) grades I-II) was 62.9 % (95 % CI, 50.0-74.9 %; I (2) = 91.1 %). Cerebrospinal fluid leakage was reported in 7.8 % (95 % CI, 4.8-11.4 %; I (2) = 49.8 %) of the patients. The mortality rate was 0.87 % (95 % CI, 0.22-1.78 %; I (2) = 4.9 %). Our meta-analysis revealed that for large VSs, very favourable results can be obtained using the retrosigmoid approach with minimal mortality, especially with respect to anatomical and functional facial nerve preservation.
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