Trial reportAnnals of biomedical engineering2013
Model-based quantification of cerebral hemodynamics as a physiomarker for Alzheimer's disease?
Trial report in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension.Cerebrovascular diseases (Basel, Switzerland) · 2014Trial
- Data-based modeling of cerebral hemodynamics quantifies impairment of cerebral blood flow regulation in type-2 diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Time-domain methods for quantifying dynamic cerebral blood flow autoregulation: Review and recommendations. A white paper from the Cerebrovascular Research Network (CARNet).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Cognitive activity significantly affects the dynamic cerebral autoregulation, but not the dynamic vasoreactivity, in healthy adults.Frontiers in physiology · 2024Article
- Functional near-infrared spectroscopy-based prefrontal cortex oxygenation during working memory tasks in sickle cell disease.Neurophotonics · 2023Article
- The Dynamic Relationship Between Cortical Oxygenation and End-TidalFrontiers in physiology · 2021Article
- Steady-state cerebral autoregulation in older adults with amnestic mild cognitive impairment: linear mixed model analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Quantification of dynamic cerebral autoregulation and COJournal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Dysregulation of CO2-Driven Heart-Rate Chemoreflex Is Related Closely to Impaired CO2 Dynamic Vasomotor Reactivity in Mild Cognitive Impairment Patients.Journal of Alzheimer's disease : JAD · 2020Article
- Comparing model-based cerebrovascular physiomarkers with DTI biomarkers in MCI patients.Brain and behavior · 2019Article
- Dynamic Cerebral Autoregulation Reproducibility Is Affected by Physiological Variability.Frontiers in physiology · 2019Article
- Multiscale modeling in the clinic: diseases of the brain and nervous system.Brain informatics · 2017Review
- Compartmental and Data-Based Modeling of Cerebral Hemodynamics: Nonlinear Analysis.IEEE transactions on bio-medical engineering · 2017Article
- Comparison of Model-Based Indices of Cerebral Autoregulation and Vasomotor Reactivity Using Transcranial Doppler versus Near-Infrared Spectroscopy in Patients with Amnestic Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2017Article
- Multiple-input nonlinear modelling of cerebral haemodynamics using spontaneous arterial blood pressure, end-tidal CO2 and heart rate measurements.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Correcting for Blood Arrival Time in Global Mean Regression Enhances Functional Connectivity Analysis of Resting State fMRI-BOLD Signals.Frontiers in human neuroscience · 2016Article
- Vascular coupling in resting-state fMRI: evidence from multiple modalities.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Principal Dynamic Mode Analysis of EEG Data for Assisting the Diagnosis of Alzheimer's Disease.IEEE journal of translational engineering in health and medicine · 2015Article
- Expression of Tau protein in rats with cognitive dysfunction induced by cerebral hypoperfusion.International journal of clinical and experimental medicine · 2015Article
- Dysregulation of cerebral perfusion dynamics is associated with Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Previous studies have found that Alzheimer's disease (AD) impairs cerebral vascular function, even at early stages of the disease. This offers the prospect of a useful diagnostic method for AD, if cerebral vascular dysfunction can be quantified reliably within practical clinical constraints. We present a recently developed methodology that utilizes a data-based dynamic nonlinear closed-loop model of cerebral hemodynamics to compute "physiomarkers" quantifying the state of cerebral flow autoregulation to pressure-changes (CA) and cerebral CO2 vasomotor reactivity (CVMR) in each subject. This model is estimated from beat-to-beat measurements of mean arterial blood pressure, mean cerebral blood flow velocity and end-tidal CO2, which can be made reliably and non-invasively under resting conditions. This model may also take an open-loop form and comparisons are made with the closed-loop counterpart. The proposed model-based physiomarkers take the form of two indices that quantify the gain of the CA and CVMR processes in each subject. It was found in an initial set of clinical data that the CVMR index delineates AD patients from control subjects and, therefore, may prove useful in the improved diagnosis of early-stage AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.