ReviewViruses2013
Expanding possibilities for intervention against small ruminant lentiviruses through genetic marker-assisted selective breeding.
Review in Viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Permissiveness of different TMEM154 genotype cell lines to different SRLV genotypes/subtypes.Journal of virology · 2025Article
- Maedi-visna infection in Pomeranian Coarsewool Sheep in Germany: seroprevalence, environmental and genetic risk factors.Frontiers in veterinary science · 2025Article
- Genetic diversity in German Pomeranian Coarsewool sheep and the possibility of breeding for maedi-visna resistance.Archives animal breeding · 2025Article
- Identification ofAnimal biotechnology · 2024Article
- Genome-wide association with footrot in hair and wool sheep.Frontiers in genetics · 2023Article
- Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility.Animals : an open access journal from MDPI · 2022Article
- Molecular Characterization of Small Ruminant Lentiviruses Isolated from Polish Goats with Arthritis.Viruses · 2022Article
- Transcriptome Analysis for Genes Associated with Small Ruminant Lentiviruses Infection in Goats of Carpathian Breed.Viruses · 2021Article
- First Survey of SNPs inViruses · 2021Article
- A DNA Regulatory Element Haplotype at Zinc Finger Genes Is Associated with Host Resilience to Small Ruminant Lentivirus in Two Sheep Populations.Animals : an open access journal from MDPI · 2021Article
- Gene Expression Profiling Reveals New Pathways and Genes Associated with Visna/Maedi Viral Disease.Animals : an open access journal from MDPI · 2021Article
- Association ofAnimals : an open access journal from MDPI · 2020Article
- Etiology, Epizootiology and Control of Maedi-Visna in Dairy Sheep: A Review.Animals : an open access journal from MDPI · 2020Review
- The EDN2 rs110287192 gene polymorphism is associated with paratuberculosis susceptibility in multibreed cattle population.PloS one · 2020Article
- Lentivirus Susceptibility in Iranian and German Sheep Assessed by Determination ofAnimals : an open access journal from MDPI · 2019Article
- First survey on association of TMEM154 and CCR5 variants with serological maedi-visna status of sheep in German flocks.Veterinary research · 2018Article
- Maedi-Visna virus: current perspectives.Veterinary medicine (Auckland, N.Z.) · 2018Review
- Review
- Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock.Animal genetics · 2014Article
- Association analysis of variant near ZNF389 with ewe cumulative production in three sheep breeds.Animal genetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic component in susceptibility to infection by OvLV in sheep. A genetic marker test for susceptibility to OvLV has been developed recently based on the TMEM154 gene with validation data from over 2,800 sheep representing nine cohorts. While no single genotype has been shown to have complete resistance to OvLV, consistent association in thousands of sheep from multiple breeds and management conditions highlight a new strategy for intervention by selective breeding. This genetic marker-assisted selection (MAS) has the potential to be a useful addition to existing viral control measures. Further, the discovery of multiple additional genomic regions associated with susceptibility to or control of OvLV suggests that additional genetic marker tests may be developed to extend the reach of MAS in the future. This review will cover the strengths and limitations of existing data from host genetics as an intervention and outline additional questions for future genetic research in sheep, goats, small ruminant lentiviruses, and their host-pathogen interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.