ArticleNucleic acids research2013
A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
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- The phage Φ13-encoded transcriptional regulator Ltr controls phage assembly in Staphylococcus aureus.Virology journal · 2026Article
- Computational Pipeline for Targeted Integration and Variable Payload Expression in Bacteriophage Engineering.ACS synthetic biology · 2025Article
- Genetics, ecology and evolution of phage satellites.Nature reviews. Microbiology · 2025Review
- Selective degradation of phage RNAs by the Csm6 ribonuclease provides robust type III CRISPR immunity in Streptococcus thermophilus.Nucleic acids research · 2024Article
- Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles.Nature microbiology · 2024Article
- The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus.Nature communications · 2023Article
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- Phage-Inducible Chromosomal Islands as a Diagnostic Platform to Capture and Detect Bacterial Pathogens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Phage transcription activator RinA regulates Staphylococcus aureus virulence by governing sarA expression.Genes & genomics · 2023Article
- Phage-inducible chromosomal islands promote genetic variability by blocking phage reproduction and protecting transductants from phage lysis.PLoS genetics · 2022Article
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- Active Lysogeny in Listeria Monocytogenes Is a Bacteria-Phage Adaptive Response in the Mammalian Environment.Cell reports · 2020Article
- Advances in bacterial transcriptome understanding: From overlapping transcription to the excludon concept.Molecular microbiology · 2020Review
- Rebooting Synthetic Phage-Inducible Chromosomal Islands: One Method to Forge Them All.Biodesign research · 2020Article
- Bacteriophage φEf11 ORF28 Endolysin, a Multifunctional Lytic Enzyme with Properties Distinct from All Other Identified Enterococcus faecalis Phage Endolysins.Applied and environmental microbiology · 2019Article
- Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals.Nature chemical biology · 2019Article
- Prevalence and Diversity Analysis of Candidate Prophages to Provide An Understanding on Their Roles inViruses · 2019Article
- Lysogenization of Staphylococcus aureus RN450 by phages ϕ11 and ϕ80α leads to the activation of the SigB regulon.Scientific reports · 2018Article
- Sak and Sak4 recombinases are required for bacteriophage replication in Staphylococcus aureus.Nucleic acids research · 2017Article
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
The propagation of bacteriophages and other mobile genetic elements requires exploitation of the phage mechanisms involved in virion assembly and DNA packaging. Here, we identified and characterized four different families of phage-encoded proteins that function as activators required for transcription of the late operons (morphogenetic and lysis genes) in a large group of phages infecting Gram-positive bacteria. These regulators constitute a super-family of proteins, here named late transcriptional regulators (Ltr), which share common structural, biochemical and functional characteristics and are unique to this group of phages. They are all small basic proteins, encoded by genes present at the end of the early gene cluster in their respective phage genomes and expressed under cI repressor control. To control expression of the late operon, the Ltr proteins bind to a DNA repeat region situated upstream of the terS gene, activating its transcription. This involves the C-terminal part of the Ltr proteins, which control specificity for the DNA repeat region. Finally, we show that the Ltr proteins are the only phage-encoded proteins required for the activation of the packaging and lysis modules. In summary, we provide evidence that phage packaging and lysis is a conserved mechanism in Siphoviridae infecting a wide variety of Gram-positive bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.