ArticleNanoscale2013
VEGF-loaded graphene oxide as theranostics for multi-modality imaging-monitored targeting therapeutic angiogenesis of ischemic muscle.
Article in Nanoscale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Theranostic applications of multifunctional carbon nanomaterials.View (Beijing, China) · 2023Article
- Progress and challenges of graphene and its congeners for biomedical applications.Journal of molecular liquids · 2022Article
- Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process.European journal of medical research · 2022Review
- Dual Function of aFrontiers in cardiovascular medicine · 2022Article
- Carbon nanomaterials for cardiovascular theranostics: Promises and challenges.Bioactive materials · 2021Review
- Liposomes: Biomedical Applications.Chonnam medical journal · 2021Review
- Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?International journal of nanomedicine · 2020Review
- Recent advances in graphene-based nanomaterials: properties, toxicity and applications in chemistry, biology and medicine.Mikrochimica acta · 2019Review
- A Review on Graphene-Based Nanomaterials in Biomedical Applications and Risks in Environment and Health.Nano-micro letters · 2018Article
- Recent strategies to design vascular theranostic nanoparticles.Nanotheranostics · 2017Review
- Graphene-based nanomaterials for bioimaging.Advanced drug delivery reviews · 2016Review
- Molecular Imaging for Comparison of Different Growth Factors on Bone Marrow-Derived Mesenchymal Stromal Cells' Survival and Proliferation In Vivo.BioMed research international · 2016Article
- An aptamer-targeting photoresponsive drug delivery system using "off-on" graphene oxide wrapped mesoporous silica nanoparticles.Nanoscale · 2015Article
- Optical and photoacoustic dual-modality imaging guided synergistic photodynamic/photothermal therapies.Nanoscale · 2015Article
- Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide.Biomaterials · 2015Article
- Surface Functionalization of Chemically Reduced Graphene Oxide for Targeted Photodynamic Therapy.Journal of biomedical nanotechnology · 2015Article
- Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia.ACS nano · 2015Review
- VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide in vivo.Biomaterials · 2015Article
- Surface engineering of graphene-based nanomaterials for biomedical applications.Bioconjugate chemistry · 2014Review
- Triphase interface synthesis of plasmonic gold bellflowers as near-infrared light mediated acoustic and thermal theranostics.Journal of the American Chemical Society · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Herein we report the design and synthesis of multifunctional VEGF-loaded IR800-conjugated graphene oxide (GO-IR800-VEGF) for multi-modality imaging-monitored therapeutic angiogenesis of ischemic muscle. The as-prepared GO-IR800-VEGF positively targets VEGF receptors, maintains an elevated level of VEGF in ischemic tissues for a prolonged time, and finally leads to remarkable therapeutic angiogenesis of ischemic muscle. Although more efforts are required to further understand the in vivo behaviors and the long-term toxicology of GO, our work demonstrates the success of using GO for efficient VEGF delivery in vivo by intravenous administration and suggests the great promise of using graphene oxide in theranostic applications for treating ischemic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.