Evidence map›Paper›PMID 23770741›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014

Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.

Brian J Morris, Timothy A Donlon, Qimei He, John S Grove, Kamal H Masaki, Ayako Elliott, D Craig Willcox, Bradley J Willcox

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Genetic and epigenetic regulation of human aging and longevity.Biochimica et biophysica acta. Molecular basis of disease · 2019
    Review
  2. Review
  3. Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018
    Article
  4. FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.Current topics in developmental biology · 2018
    Article
  5. Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Brian J MorrisDSc Honolulu Heart Program (HHP)/Honolulu-Asia Aging Study (HAAS), Kuakini Medical Center, 347 North Kuakini Street, HPM-9, Honolulu, Hawaii 96817. brian.morris@sydney.edu.au.
Timothy A Donlon
Qimei He
John S Grove
Kamal H Masaki
Ayako Elliott
D Craig Willcox
Bradley J Willcox
University of Hawaiʻi at Mānoa · USOkinawa International University · JP

Funding

FOXO3 Genotype, InflammAging, Cardiovascular Disease, and Dementia. Kuakini Hawaii Lifespan Study III. Administrative Supplement.R01AG027060 · NIA · KUAKINI MEDICAL CENTER · PI Gregory J. Tranah, BRADLEY JOHN WILLCOX · 2005 to 2026
$8.1M
Energy-sensing Pathways, Healthy Aging and LongevityR01AG038707 · NIA · KUAKINI MEDICAL CENTER · PI WILLCOX, BRADLEY JOHN · 2011 to 2014
$1.4M
NIA NIH HHS 5R01AG027060-06NIA NIH HHS 5R01AG038707-02NIA NIH HHS R01 AG027060NIA NIH HHS R01 AG038707
6 · The paper itself

Abstract

Evidence from model organisms suggests that the insulin/IGF-1 signaling pathway has an important, evolutionarily conserved influence over rate of aging and thus longevity. In humans, the FOXO3 gene is the only widely replicated insulin/IGF-1 signaling pathway gene associated with longevity across multiple populations. Therefore, we conducted a nested case-control study of other insulin/IGF-1 signaling genes and longevity, utilizing a large, homogeneous, long-lived population of American men of Japanese ancestry, well characterized for aging phenotypes. Genotyping was performed of single nucleotide polymorphisms, tagging most of the genetic variation across several genes in the insulin/IGF-1 signaling pathway or related gene networks that may be influenced by FOXO3, namely, ATF4, CBL, CDKN2, EXO1, and JUN. Two initial, marginal associations with longevity did not remain significant after correction for multiple comparisons, nor were they correlated with aging-related phenotypes.

Indexed as

Activating Transcription Factor 4Aged, 80 and overAgingAsianCase-Control StudiesCohort StudiesDNA Repair EnzymesExodeoxyribonucleasesForkhead Box Protein O3Forkhead Transcription FactorsGene FrequencyGenes, junGenes, p16Genetic VariationGenotypeHumansActivating Transcription Factor 4ATF4 protein, humanCBL protein, humanDNA Repair EnzymesEXO1 protein, humanExodeoxyribonucleasesForkhead Box Protein O3Forkhead Transcription FactorsFOXO3 protein, humanInsulinInsulin-Like Growth Factor IProto-Oncogene Proteins c-cblHuman.Insulin signaling genesLongevityMolecular genetics

Identifiers

PMID23770741
PMCPMC3968832
OpenAlexW2148199714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.