Evidence map›Paper›PMID 23770714›Full record

ArticleCellular immunology2013

Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats.

Douglas A Weigent

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Douglas A WeigentDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., MCLM894, Birmingham, AL 35294-0005, USA. Weigent@uab.edu
University of Alabama at Birmingham · US

Funding

PRODUCTION AND FUNCTION OF GHRH IN THE IMMUNE SYSTEMR01AI041651 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEIGENT, DOUGLAS A · 1997 to 2003
$731k
LYMPHOCYTE-DERIVED HORMONES:STRUCTURE,FUNCTION AND CONTRR01DK038024 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J. EDWIN · 1986 to 1994
–
GROWTH HORMONE AND THE IMMUNE SYSTEMR01NS024636 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEIGENT, DOUGLAS A · 1988 to 1993
–
NIAID NIH HHS R01 AI041651NIDDK NIH HHS R01 DK38024NINDS NIH HHS R01 NS24636
6 · The paper itself

Abstract

In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH induction after treatment with GHRH. Taken together, the data for the first time show alterations in GH synthesis and expression of the GHRH receptor on cells of the immune system that may play a role in the immune response in aging.

Indexed as

AgingAnimalsBlotting, WesternB-LymphocytesCell ProliferationCells, CulturedFemaleGene ExpressionGrowth HormoneGrowth Hormone-Releasing HormoneLeukocytesLymphocytesMiceMice, Inbred C57BLRatsRats, Sprague-DawleyGrowth HormoneGrowth Hormone-Releasing HormoneReceptors, NeuropeptideReceptors, Pituitary Hormone-Regulating HormoneRNAsomatotropin releasing hormone receptorAgingGHRH receptorsGrowth hormoneLymphocytes

Identifiers

PMID23770714
PMCPMC3736351
OpenAlexW1978743139

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.