ArticleNature genetics2013
Whole-genome sequence-based analysis of high-density lipoprotein cholesterol.
Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.
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Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Epigenome-wide association study of mitochondrial genome copy number.Human molecular genetics · 2021Pooled it
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.Nature genetics · 2014Pooled it
- Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: the Family Blood Pressure Program.Atherosclerosis · 2014Pooled it
- Development, testing and comparison of novel lifestyle-based prediction models for risk of coronary heart disease.Scientific reports · 2025Article
- De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data.Genome research · 2025Article
- De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data.bioRxiv : the preprint server for biology · 2024Article
- Rare variants at KCNJ2 are associated with LDL-cholesterol levels in a cross-population study.NPJ genomic medicine · 2024Article
- eSCAN: scan regulatory regions for aggregate association testing using whole-genome sequencing data.Briefings in bioinformatics · 2022Article
- A Novel Hierarchical Clustering Approach for Joint Analysis of Multiple Phenotypes Uncovers Obesity Variants Based on ARIC.Frontiers in genetics · 2022Article
- Predicting deleterious missense genetic variants via integrative supervised nonnegative matrix tri-factorization.Scientific reports · 2021Article
- locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies.Genetic epidemiology · 2021Article
- A Novel Approach Integrating Hierarchical Clustering and Weighted Combination for Association Study of Multiple Phenotypes and a Genetic Variant.Frontiers in genetics · 2021Article
- Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis.PLoS genetics · 2020Article
- [An improved association analysis pipeline for tumor susceptibility variant in haplotype amplification area].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Convex combination sequence kernel association test for rare-variant studies.Genetic epidemiology · 2020Article
- Article
- Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers.Scientific reports · 2019Article
- Article
- Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies.American journal of human genetics · 2019Article
- High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2019Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors.
Funding
Abstract
We describe initial steps for interrogating whole-genome sequence data to characterize the genetic architecture of a complex trait, levels of high-density lipoprotein cholesterol (HDL-C). We report whole-genome sequencing and analysis of 962 individuals from the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) studies. From this analysis, we estimate that common variation contributes more to heritability of HDL-C levels than rare variation, and screening for mendelian variants for dyslipidemia identified individuals with extreme HDL-C levels. Whole-genome sequencing analyses highlight the value of regulatory and non-protein-coding regions of the genome in addition to protein-coding regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.