ReviewRespiratory physiology & neurobiology2013
Central and peripheral factors contributing to obstructive sleep apneas.
Review in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 100 citations in OpenAlex.
- Circuit Mechanisms Underlying the Contribution of Leptin Receptor-Expressing Neurons in the Nucleus Tractus Solitarius to Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- Quantification of ventilatory control in sleep apnea: from physiological insight to computable loop gain.Sleep · 2026Review
- KalinixSleep & breathing = Schlaf & Atmung · 2026Article
- Unraveling sleep apnea dynamics: quantifying loop gain using dynamical modeling of ventilatory control.Sleep · 2026Article
- Sighs Shape Respiratory Variability and Pupil Dynamics and Adapt to Sustained Attention Demands.Psychophysiology · 2026Article
- Divergent ventilatory responses during opioid-induced respiratory depression in response to repeated fentanyl use.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Article
- Chronic Intermittent Hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production.bioRxiv : the preprint server for biology · 2024Article
- Evaluation of the Continuous Positive Airway Pressure Effect on Neurotrophins' Gene Expression and Protein Levels.International journal of molecular sciences · 2023Article
- Drive versus Pressure Contributions to Genioglossus Activity in Obstructive Sleep Apnea.Annals of the American Thoracic Society · 2023Article
- DMSO potentiates the suppressive effect of dronabinol on sleep apnea and REM sleep in rats.Journal of cannabis research · 2023Article
- Insights into the Use of Point-of-Care Ultrasound for Diagnosing Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2023Review
- A narrative review of the mechanisms and consequences of intermittent hypoxia and the role of advanced analytic techniques in pediatric autonomic disorders.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Review
- A Consequence of Immature Breathing induces Persistent Changes in Hippocampal Synaptic Plasticity and Behavior: A Role of Pro-Oxidant State and NMDA Receptor Imbalance.bioRxiv : the preprint server for biology · 2023Article
- Central Apneic Event Prevalence in REM and NREM Sleep in OSA Patients: A Retrospective, Exploratory Study.Biology · 2023Article
- A consequence of immature breathing induces persistent changes in hippocampal synaptic plasticity and behavior: a role of prooxidant state and NMDA receptor imbalance.Frontiers in molecular neuroscience · 2023Article
- Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer's disease.Nature communications · 2022Article
- Serum neurofilament light reflects cognitive dysfunctions in children with obstructive sleep apnea.BMC pediatrics · 2022Article
- Mafa-dependent GABAergic activity promotes mouse neonatal apneas.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Apnea, the cessation of breathing, is a common physiological and pathophysiological phenomenon. Among the different forms of apnea, obstructive sleep apnea (OSA) is clinically the most prominent manifestation. OSA is characterized by repetitive airway occlusions that are typically associated with peripheral airway obstructions. However, it would be an oversimplification to conclude that OSA is caused by peripheral obstructions. OSA is the result of a dynamic interplay between chemo- and mechanosensory reflexes, neuromodulation, behavioral state and the differential activation of the central respiratory network and its motor outputs. This interplay has numerous neuronal and cardiovascular consequences that are initially adaptive but in the long-term become major contributors to morbidity and mortality. Not only OSA, but also central apneas (CA) have multiple, and partly overlapping mechanisms. In OSA and CA the underlying mechanisms are neither "exclusively peripheral" nor "exclusively central" in origin. This review discusses the complex interplay of peripheral and central nervous components that characterizes the cessation of breathing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.