ArticleRespiratory physiology & neurobiology2013
Influence of parenchymal heterogeneity on airway-parenchymal interdependence.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A scale-free model of acute and ventilator-induced lung injury: a network theory approach inspired by seismology.Frontiers in network physiology · 2024Article
- Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence.Annals of biomedical engineering · 2023Article
- Predicting alveolar ventilation heterogeneity in pulmonary fibrosis using a non-uniform polyhedral spring network model.Frontiers in network physiology · 2023Article
- Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Whole-lung finite-element models for mechanical ventilation and respiratory research applications.Frontiers in physiology · 2022Article
- Surfactant-Mediated Airway and Acinar Interactions in a Multi-Scale Model of a Healthy Lung.Frontiers in physiology · 2020Article
- Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?American journal of respiratory and critical care medicine · 2019Review
- Alveolar Micromechanics in Bleomycin-induced Lung Injury.American journal of respiratory cell and molecular biology · 2018Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- Dynamics of airway response in lung microsections: a tool for studying airway-extra cellular matrix interactions.Journal of biomedical science · 2016Review
- Modeling the Progression of Epithelial Leak Caused by Overdistension.Cellular and molecular bioengineering · 2016Article
- Resistance to alveolar shape change limits range of force propagation in lung parenchyma.Respiratory physiology & neurobiology · 2015Article
- Spatial pattern formation in the lung.Journal of mathematical biology · 2015Article
- Mechanical interactions between adjacent airways in the lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
To estimate the influence of parenchymal heterogeneities on airway-parenchymal interdependence, we considered a circular airway embedded within elastic parenchyma modeled as (1) a hexagonal spring network, (2) a triangular spring network, or (3) a continuum. The deformation in the parenchyma due to active airway contraction was simulated using the finite element method. Random perturbations of elastic moduli in the parenchyma did not significantly affect the overall pattern of force transmission. By contrast, when elastic moduli were increased along a path projecting radially outward from the airway, the hexagonal spring network model predicted significantly increased force along this line as the airway contracted, but this was not observed in other two models. These results indicate that tissue heterogeneities generally have minimal effect on the global nature of airway-parenchymal interdependence. However, in the exceptional circumstance of scar tissue aligned radially from the airway wall, parenchymal distortion forces may propagate much farther from the airway wall than was previously thought.
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