ArticleCurrent biology : CB2013
Specific kinematics and motor-related neurons for aversive chemotaxis in Drosophila.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Response Plasticity ofInternational journal of molecular sciences · 2024Article
- Olfactory stimuli and moonwalker SEZ neurons can drive backward locomotion in Drosophila.Current biology : CB · 2022Article
- Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21.Cancer research · 2022Article
- The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells.International journal of molecular sciences · 2021Article
- WalkingeLife · 2020Article
- Neurogenetic dissection of theeLife · 2019Article
- Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer.Journal of visualized experiments : JoVE · 2016Article
- Article
- Article
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- Improved and expanded Q-system reagents for genetic manipulations.Nature methods · 2015Article
- Extremely sparse olfactory inputs are sufficient to mediate innate aversion in Drosophila.PloS one · 2015Article
- Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila.Cell reports · 2014Article
- Article
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7 authors.
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Abstract
backgroundChemotaxis, the ability to direct movements according to chemical cues in the environment, is important for the survival of most organisms. The vinegar fly, Drosophila melanogaster, displays robust olfactory aversion and attraction, but how these behaviors are executed via changes in locomotion remains poorly understood. In particular, it is not clear whether aversion and attraction bidirectionally modulate a shared circuit or recruit distinct circuits for execution.
resultsUsing a quantitative behavioral assay, we determined that both aversive and attractive odorants modulate the initiation and direction of turns but display distinct kinematics. Using genetic tools to perturb these behaviors, we identified specific populations of neurons required for aversion, but not for attraction. Inactivation of these populations of cells affected the completion of aversive turns, but not their initiation. Optogenetic activation of the same populations of cells triggered a locomotion pattern resembling aversive turns. Perturbations in both the ellipsoid body and the ventral nerve cord, two regions involved in motor control, resulted in defects in aversion.
conclusionsAversive chemotaxis in vinegar flies triggers ethologically appropriate kinematics distinct from those of attractive chemotaxis and requires specific motor-related neurons.
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