ArticleJournal of affective disorders2013
Posterior cerebellar vermal deficits in bipolar disorder.
Article in Journal of affective disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- Cerebellar gray matter volume difference in first-episode bipolar and unipolar depression.BMC psychiatry · 2026Article
- Associations between cerebellum and major psychiatric disorders: a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Differential impact of manic versus depressive episode recurrence on longitudinal gray matter volume changes in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Arachnoid Cyst in the Posterior Fossa and Its Contested Association with Mania and Psychotic Symptoms in a Prepubertal Child: A Case Report.International medical case reports journal · 2026Article
- Multimodal MRI study of gray matter and functional connectivity abnormalities in adolescents with bipolar disorder.Frontiers in psychiatry · 2025Article
- A Virtual In Vivo Dissection and Analysis of Socioaffective Symptoms Related to Cerebellum-Midbrain Reward Circuitry in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- AnbioRxiv : the preprint server for biology · 2024Article
- Review
- Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I.Journal of affective disorders · 2023Article
- The Cerebellum Gets Social: Evidence from an Exploratory Study of Cerebellar, Neurodevelopmental, and Psychiatric Disorders.Biomedicines · 2023Article
- A missing link in affect regulation: the cerebellum.Social cognitive and affective neuroscience · 2022Review
- Aberrant Neural Response to Social Exclusion Without Significantly Greater Distress in Youth With Bipolar Disorder: Preliminary Findings.Frontiers in psychiatry · 2022Article
- Cerebellum and Emotion in Social Behavior.Advances in experimental medicine and biology · 2022Article
- Comparison of Cerebellar Grey Matter Alterations in Bipolar and Cerebellar Patients: Evidence from Voxel-Based Analysis.International journal of molecular sciences · 2021Article
- Consensus Paper: Cerebellum and Social Cognition.Cerebellum (London, England) · 2020Review
- Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder.Frontiers in psychiatry · 2020Article
- Aberrant cerebellar connectivity in bipolar disorder with psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Consensus Paper: Cerebellum and Emotion.Cerebellum (London, England) · 2017Article
- Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study.Schizophrenia bulletin · 2016Article
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10 authors.
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Abstract
backgroundBased on growing evidence of the crucial role of the cerebellum in emotional regulation, we sought to identify cerebellar structural deficits in a large sample of patients with bipolar disorder (BD).
methodsCerebellar gray matter density was examined in 49 BD patients (24 medication-naive and 25 medication-treated) and 50 carefully matched healthy individuals, using voxel-based morphometry with a high-resolution spatially unbiased atlas template of the human cerebellum. This recently developed methodology is specifically optimized for the assessment of cerebellar structures. We further explored whether antimanic treatment could attenuate cerebellar structural deficits.
resultsBD patients showed a greater reduction in gray matter density of the posterior cerebellar regions, including the bilateral vermi and the right crus relative to healthy individuals (corrected p<.05). A stepwise linear reduction in gray matter density was observed in bilateral vermal regions between healthy individuals, medication-treated, and medication-naive BD patients. Furthermore, positive correlations of longer duration of illness with bilateral vermal gray matter deficits were observed only in medication-naive BD patients, but not in patients with medication history. LIMITATIONS: This study adopted a cross-sectional design. The automatic intensity-normalization method for the measurement of cerebellar gray matter density may have a limitation in providing detailed anatomical information at a cerebellar folia level.
conclusionsThe current findings suggest that BD-related deficits in the posterior cerebellar regions, which appear to progress over the course of illness, could potentially be ameliorated by proper treatment with mood stabilizers.
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