Evidence map›Paper›PMID 23769598›Full record

ArticleThe Lancet. Neurology2013

Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease.

Giselle M Petzinger, Beth E Fisher, Sarah McEwen, Jeff A Beeler, John P Walsh, Michael W Jakowec

6 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 375 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
375citing papers in PubMed, 19 pooled it
26.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02433691 nacompletednot on this mapstarted 2015, after this paper: background citation

Simultaneous Aerobic Exercise and Memory Training in Older Adults With Subjective Memory Complaints

TypeinterventionalSponsorDavid Merrill, MD, PhDRan2015 to 2017Enrolled60ConditionsMemory ImpairmentArmssimultaneous aerobic exercise, sequential aerobic exercise, stretching and toning
NCT03333837 nacompletednot on this mapstarted 2018, after this paper: background citation

IMOVE: Improvisational Movement for People With Memory Loss and Their Caregivers

TypeinterventionalSponsorWake Forest University Health SciencesRan2018 to 2021Enrolled104ConditionsAlzheimer's Disease (Incl Subtypes), Dementia, Mild Cognitive ImpairmentArmsDance Group, Non-Group Dance, Social Group, No Contact
NCT03517371 nacompletednot on this mapstarted 2019, after this paper: background citation

Walking and mHealth to Increase Participation in Parkinson Disease

TypeinterventionalSponsorBoston University Charles River CampusRan2019 to 2024Enrolled140ConditionsParkinson DiseaseArmsmHealth delivered exercise program, Exercise only
NCT04012086 nacompletednot on this mapstarted 2015, after this paper: background citation

Intensive Physical Therapy Mitigates Cognitive Decline in People With Parkinson's Disease

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled40ConditionsParkinson Disease, Cognitive ImpairmentArmsPhysical therapy
NCT04237025 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Nordic Walking Exercise on Gait, Motor/Non-motor Symptoms, and Exercise Biomarkers in Individuals With Parkinson's Disease

TypeinterventionalSponsorGrand Valley State UniversityRan2021 to 2021Enrolled12ConditionsParkinson DiseaseArmsNordic walking exercise
NCT05538455 nacompletednot on this mapstarted 2022, after this paper: background citation

ProCare4Life Pilot 3 Clinical Study: Investigating ProCare4Life Impact on Quality of Life of Elderly Subjects With Neurodegenerative Diseases

TypeinterventionalSponsorCasa di Cura Privata del Policlinico SpARan2022 to 2023Enrolled558ConditionsNeurodegenerative Diseases, Parkinson Disease, Alzheimer Disease, Quality of LifeArmsPC4L solutions
3 · Its place in the literature

Who cites it

375 citing papers in PubMed, 19 syntheses or guidelines pooled it, 764 citations in OpenAlex.

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  6. Combined exercise training to improve gait in older stroke patients: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  20. Trial

315 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Giselle M PetzingerDepartment of Neurology, University of Southern California, Los Angeles, CA 90089, USA. gpetzinger@surgery.usc.edu
Beth E Fisher
Sarah McEwen
Jeff A Beeler
John P Walsh
Michael W Jakowec
University of Southern California · USNeurobehavioral Systems · USUniversity of Chicago · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced RecoveryR01NS044327 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAKOWEC, MICHAEL WALTER, WALSH, JOHN P · 2002 to 2010
$1.8M
Biological Mechanisms of Enhanced Neuroplasticity in First-Episode SchizophreniaK01MH099431 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCEWEN, SARAH CHRISTINE · 2012 to 2016
$829k
NCATS NIH HHS UL1 TR000130NIMH NIH HHS K01 MH099431NINDS NIH HHS R01 NS044327
6 · The paper itself

Abstract

Exercise interventions in individuals with Parkinson's disease incorporate goal-based motor skill training to engage cognitive circuitry important in motor learning. With this exercise approach, physical therapy helps with learning through instruction and feedback (reinforcement) and encouragement to perform beyond self-perceived capability. Individuals with Parkinson's disease become more cognitively engaged with the practice and learning of movements and skills that were previously automatic and unconscious. Aerobic exercise, regarded as important for improvement of blood flow and facilitation of neuroplasticity in elderly people, might also have a role in improvement of behavioural function in individuals with Parkinson's disease. Exercises that incorporate goal-based training and aerobic activity have the potential to improve both cognitive and automatic components of motor control in individuals with mild to moderate disease through experience-dependent neuroplasticity. Basic research in animal models of Parkinson's disease is beginning to show exercise-induced neuroplastic effects at the level of synaptic connections and circuits.

Indexed as

Exercise TherapyAnimalsCognitionDendritic SpinesDisease Models, AnimalExerciseGoalsHealth StatusHumansMPTP PoisoningNeural PathwaysNeurogenesisNeuronal PlasticityParkinson Disease

Identifiers

PMID23769598
PMCPMC3690528
OpenAlexW2143978324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.