Evidence map›Paper›PMID 23769497›Full record

ArticleThe Journal of pediatrics2013

Childhood asthma hospitalizations in the United States, 2000-2009.

Kohei Hasegawa, Yusuke Tsugawa, David F M Brown, Carlos A Camargo

2 registry-linked trialsAbstract read
In one paragraph

Article in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03513458 phase1 / phase2withdrawnnot on this mapstarted 2020, after this paper: background citation

Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2020 to 2021Enrolled0ConditionsAsthmaArmsAnakinra, Anakinra Matching Placebo, Dermatophagoides Farinae
NCT03513471 phase1 / phase2withdrawnnot on this mapstarted 2019, after this paper: background citation

Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2021Enrolled0ConditionsAsthmaArmsAnakinra, Anakinra Matching Placebo, Dermatophagoides Farinae
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Non-invasive positive pressure ventilation for acute asthma in children.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Review
  3. Pediatric asthma population risk stratification using k-means clustering.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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  10. Article
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  12. Article
  13. Article
  14. Review
  15. Risk Factors and Outcomes Associated With Antibiotic Therapy in Children Hospitalized With Asthma Exacerbation.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
  16. Article
  17. Inpatient Pediatric CKD Health Care Utilization and Mortality in the United States.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
    Article
  18. Article
  19. Pediatric asthma pathway in the emergency room.Proceedings (Baylor University. Medical Center) · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kohei HasegawaMassachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: khasegawa1@partners.org.
Yusuke Tsugawa
David F M Brown
Carlos A Camargo

Funding

Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent WheezingU01AI087881 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, CARLOS ARTURO · 2011 to 2016
$6.2M
NIAID NIH HHS U01 AI087881NIAID NIH HHS U01 AI-87881
6 · The paper itself

Abstract

objectiveTo examine temporal trends in the US incidence of childhood asthma hospitalizations, in-hospital mortality, mechanical ventilation use, and hospital charges between 2000 and 2009. STUDY

designThis was a serial, cross-sectional analysis of a nationally representative sample of children hospitalized with acute asthma. The Kids Inpatient Database was used to identify children aged <18 years with asthma by International Classification of Diseases, Ninth Revision, Clinical Modification code 493.xx. Outcome measures were asthma hospitalization incidence, in-hospital mortality, mechanical ventilation use, and hospital charges. We examined temporal trends of each outcome, accounting for sampling weights. Hospital charges were adjusted for inflation to 2009 US dollars.

resultsThe 4 separate years (2000, 2003, 2006, and 2009) of national discharge data included a total of 592805 weighted discharges with asthma. Between 2000 and 2009, the rate of asthma hospitalization in US children decreased from 21.1 to 18.4 per 10000 person-years (13% decrease; Ptrend < .001). Mortality declined significantly after adjusting for confounders (OR for comparison of 2009 with 2000, 0.37; 95% CI, 0.17-0.79). In contrast, there was an increase in the use of mechanical ventilation (from 0.8% to 1.0%, a 28% increase; Ptrend < .001). Nationwide hospital charges also increased from $1.27 billion to $1.59 billion (26% increase; Ptrend < .001); this increase was driven by a rise in the geometric mean of hospital charges per discharge, from $5940 to $8410 (42% increase; Ptrend < .001).

conclusionBetween 2000 and 2009, we found significant declines in asthma hospitalization and in-hospital mortality among US children. In contrast, mechanical ventilation use and hospital charges for asthma increased significantly over this same period.

Indexed as

AdolescentAsthmaChildChild, PreschoolCross-Sectional StudiesDatabases, FactualFemaleHealth Care CostsHospital ChargesHospitalizationHospital MortalityHumansIncidenceInfantMaleRespiration, ArtificialAgency for Healthcare Research and QualityAHRQCCSClinical Classifications SoftwareHCUPHealthcare Cost and Utilization ProjectICD-9-CMInternational Classification of Diseases, Ninth Revision, Clinical ModificationKIDKids' Inpatient Database

Identifiers

PMID23769497
PMCPMC3786053

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.