ArticlePsychiatry research2013
White matter microstructure abnormalities and executive function in adolescents with prenatal cocaine exposure.
Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- Enhancing daily life for children with cognitive developmental delay through insights into brain development.Pediatric research · 2024Review
- DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study.AJNR. American journal of neuroradiology · 2023Article
- Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.Drug and alcohol dependence · 2022Article
- The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users.Addiction biology · 2022Article
- Neuroimaging in infants with prenatal opioid exposure: Current evidence, recent developments and targets for future research.Journal of neuroradiology = Journal de neuroradiologie · 2021Review
- What proportion of the brain structural and functional abnormalities observed among children with fetal alcohol spectrum disorder is explained by their prenatal alcohol exposure and their other prenatal and postnatal risks?Advances in pediatric research · 2020Article
- Diffusion MRI of white matter microstructure development in childhood and adolescence: Methods, challenges and progress.Developmental cognitive neuroscience · 2018Review
- White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine.Drug and alcohol dependence · 2017Article
- Structural imaging for addiction medicine: From neurostructure to neuroplasticity.Progress in brain research · 2016Review
- White matter abnormalities and impaired attention abilities in children born very preterm.NeuroImage · 2016Article
- Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco.Developmental cognitive neuroscience · 2015Article
- Altered white matter in cocaine-dependent subjects with traumatic brain injury: A diffusion tensor imaging study.Drug and alcohol dependence · 2015Article
- Developmental consequences of fetal exposure to drugs: what we know and what we still must learn.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Effect of cocaine dependence on brain connections: clinical implications.Expert review of neurotherapeutics · 2015Review
- Prenatal cocaine exposure and age of sexual initiation: direct and indirect effects.Drug and alcohol dependence · 2014Article
- Adolescent risk-taking as a function of prenatal cocaine exposure and biological sex.Neurotoxicology and teratologyArticle
- Prenatal drug exposure and executive function in early adolescence.Neurotoxicology and teratologyArticle
- Executive function in children with prenatal cocaine exposure (12-15years).Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Children with prenatal exposure to cocaine are at higher risk for negative behavioral function and attention difficulties, and have demonstrated brain diffusion abnormalities in frontal white matter regions. However, brain regions beyond frontal and callosal areas have not been investigated using diffusion tensor imaging (DTI). DTI data were collected on 42 youth aged 14-16 years; subjects were divided into three groups based on detailed exposure histories: those with prenatal exposure to cocaine but not alcohol (prenatal cocaine exposure (PCE), n=12), prenatal exposure to cocaine and alcohol (cocaine and alcohol exposure (CAE), n=17), and controls (n=13). Tractography was performed and along-tract diffusion parameters were examined for group differences and correlations with executive function measures. In the right arcuate fasciculus and cingulum, the CAE group had higher fractional anisotropy (FA) and/or lower mean diffusivity (MD) than the other two groups. The PCE group demonstrated lower FA in the right arcuate and higher MD in the splenium of the corpus callosum than controls. Diffusion parameters in tracts with group differences correlated with measures of executive function. In conclusion, these diffusion differences in adolescents with prenatal cocaine exposure suggest localized, long-term structural brain alterations that may underlie attention and response-inhibition difficulties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.