ReviewMolecular oncology2013
Translating next generation sequencing to practice: opportunities and necessary steps.
Review in Molecular oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unsolved challenges of clinical whole-exome sequencing: a systematic literature review of end-users' views.BMC medical genomics · 2016Pooled it
- Transformative Applications and Innovations in Next-Generation Sequencing Data Analysis.Journal of applied genetics · 2026Review
- Array comparative genomic hybridisation in haematological malignancies: A comprehensive review.African journal of laboratory medicine · 2026Review
- Adaptation of PCR-based library preparation for MGI platform for cancer mutation testing in clinical setting.PloS one · 2025Article
- Genes to therapy: a comprehensive literature review of whole-exome sequencing in neurology and neurosurgery.European journal of medical research · 2024Review
- PANACEA: network-based methods for pharmacotherapy prioritization in personalized oncology.Bioinformatics (Oxford, England) · 2023Article
- Variant biomarker discovery using mass spectrometry-based proteogenomics.Frontiers in aging · 2023Review
- A Novel Predictive Model Incorporating Ferroptosis-Related Gene Signatures for Overall Survival in Patients with Lung Adenocarcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.Genome medicine · 2018Article
- Next-generation sequencing: recent applications to the analysis of colorectal cancer.Journal of translational medicine · 2017Review
- Towards precision medicine: discovering novel gynecological cancer biomarkers and pathways using linked data.Journal of biomedical semantics · 2017Article
- CloneCNA: detecting subclonal somatic copy number alterations in heterogeneous tumor samples from whole-exome sequencing data.BMC bioinformatics · 2016Article
- ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients.Genome medicine · 2015Article
- Genetics, biomarkers, hereditary cancer syndrome diagnosis, heterogeneity and treatment: a review.Current treatment options in oncology · 2014Review
- Describing sequencing results of structural chromosome rearrangements with a suggested next-generation cytogenetic nomenclature.American journal of human genetics · 2014Article
- A new model for reimbursing genome-based cancer care.The oncologist · 2014Article
- Clinical integration of next generation sequencing: coverage and reimbursement challenges.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2014Article
- Translating next generation sequencing to practice: opportunities and necessary steps.Molecular oncology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Next-generation sequencing (NGS) approaches for measuring RNA and DNA benefit from greatly increased sensitivity, dynamic range and detection of novel transcripts. These technologies are rapidly becoming the standard for molecular assays and represent huge potential value to the practice of oncology. However, many challenges exist in the transition of these technologies from research application to clinical practice. This review discusses the value of NGS in detecting mutations, copy number changes and RNA quantification and their applications in oncology, the challenges for adoption and the relevant steps that are needed for translating this potential to routine practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.