ArticleAmerican journal of ophthalmology2013
Accuracy of the Heidelberg Spectralis in the alignment between near-infrared image and tomographic scan in a model eye: a multicenter study.
Article in American journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Correlation of Optical Coherence Tomography and Autofluorescence in the Outer Retina and Choroid of Patients With Choroideremia.Investigative ophthalmology & visual science · 2016Trial
- Review
- A three-dimensional multi-modal foundation model for optical coherence tomography.Nature biomedical engineering · 2026Article
- Recent Optical Coherence Tomography (OCT) Innovations for Increased Accessibility and Remote Surveillance.Bioengineering (Basel, Switzerland) · 2025Review
- High-resolution structural and functional retinal imaging in the awake behaving mouse.Communications biology · 2023Article
- Mapping the thickness of retinal layers using Spectralis spectral domain optical coherence tomography in Indian eyes.Indian journal of ophthalmology · 2022Article
- Structural Confirmation of Lymphatic Outflow from Subconjunctival Blebs of Live Human Subjects.Ophthalmology science · 2021Article
- Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials.Progress in retinal and eye research · 2021Review
- Functional, structural, and molecular identification of lymphatic outflow from subconjunctival blebs.Experimental eye research · 2020Article
- QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION.Retina (Philadelphia, Pa.) · 2018Article
- Polarization Variability in Age-related Macular Degeneration.Optometry and vision science : official publication of the American Academy of Optometry · 2018Article
- Angiographic and structural imaging using high axial resolution fiber-based visible-light OCT.Biomedical optics express · 2017Article
- [Quality assurance of optical coherence tomography for diagnostics of the fundus : Positional statement of the BVA, DOG and RG].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Review
- [Pitfalls in retinal optical coherence tomography imaging].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2017Review
- Article
- RETICULAR PSEUDODRUSEN ON INFRARED IMAGING ARE TOPOGRAPHICALLY DISTINCT FROM SUBRETINAL DRUSENOID DEPOSITS ON EN FACE OPTICAL COHERENCE TOMOGRAPHY.Retina (Philadelphia, Pa.) · 2015Article
- Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature.BioMed research international · 2015Review
- Correlations among near-infrared and short-wavelength autofluorescence and spectral-domain optical coherence tomography in recessive Stargardt disease.Investigative ophthalmology & visual science · 2014Article
- Pointwise Structure-Function Analysis of the Ellipsoid Zone in Retinitis Pigmentosa Using an Artificial Intelligence-Assisted OCT and Microperimetry Overlay.Ophthalmology scienceArticle
- Bleb-related Porcine Lymphatic Outflow is Greater from Subconjunctival compared to Subtenon Blebs.Journal of current glaucoma practiceArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
purposeTo evaluate temporal changes and predictors of accuracy in the alignment between simultaneous near-infrared image and optical coherence tomography (OCT) scan on the Heidelberg Spectralis using a model eye.
designLaboratory investigation.
methodsAfter calibrating the device, 6 sites performed weekly testing of the alignment for 12 weeks using a model eye. The maximum error was compared with multiple variables to evaluate predictors of inaccurate alignment. Variables included the number of weekly scanned patients, total number of OCT scans and B-scans performed, room temperature and its variation, and working time of the scanning laser. A 4-week extension study was subsequently performed to analyze short-term changes in the alignment.
resultsThe average maximum error in the alignment was 15 ± 6 μm; the greatest error was 35 μm. The error increased significantly at week 1 (P = .01), specifically after the second imaging study (P < .05); reached a maximum after the eighth patient (P < .001); and then varied randomly over time. Predictors for inaccurate alignment were temperature variation and scans per patient (P < .001). For each 1 unit of increase in temperature variation, the estimated increase in maximum error was 1.26 μm. For the average number of scans per patient, each increase of 1 unit increased the error by 0.34 μm.
conclusionOverall, the accuracy of the Heidelberg Spectralis was excellent. The greatest error happened in the first week after calibration, and specifically after the second imaging study. To improve the accuracy, room temperature should be kept stable and unnecessary scans should be avoided. The alignment of the device does not need to be checked on a regular basis in the clinical setting, but it should be checked after every other patient for more precise research purposes.
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