Evidence map›Paper›PMID 23768868›Full record

ArticleLeukemia research2013

Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.

Yingtai Chen, Qing Lan, Tongzhang Zheng, Nan Zhao, Theodore R Holford, Catherine Lerro, Min Dai, Huang Huang, Jiaxin Liang, Shuangge Ma and 5 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes.International journal of clinical and experimental pathology · 2015
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Yingtai ChenCancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, China.
Qing Lan
Tongzhang Zheng
Nan Zhao
Theodore R Holford
Catherine Lerro
Min Dai
Huang Huang
Jiaxin Liang
Shuangge Ma
Brian Leaderer
Peter Boyle
Stephen Chanock
Nathaniel Rothman
Yawei Zhang
Yale University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNDivision of Cancer Epidemiology and GeneticsInternational Prevention Research Institute · FRNational Cancer Institute · US

Funding

Research Training for Cancer Epidemiology & Biostatistics in ChinaD43TW008323 · FIC · YALE UNIVERSITY · PI HOLFORD, THEODORE R, ZHENG, TONGZHANG · 2009 to 2013
$1.1M
Research Training for Study of Air Pollution Control in ChinaD43TW007864 · FIC · YALE UNIVERSITY · PI ZHENG, TONGZHANG · 2007 to 2011
$706k
Air pollution and fetal growth in ChinaK02HD070324 · NICHD · YALE UNIVERSITY · PI ZHANG, YAWEI · 2011 to 2015
$582k
Robust rank-based methods and detection of GXE in cancer etiology and survivalR21CA165923 · NCI · YALE UNIVERSITY · PI MA, SHUANGGE, ZHANG, YAWEI · 2012 to 2014
$421k
HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMAR01CA062006 · NCI · YALE UNIVERSITY · PI ZHENG, TONGZHANG · 1995 to 2000
$125k
FIC NIH HHS 1D43TW007864FIC NIH HHS 1D43TW008323FIC NIH HHS D43 TW007864FIC NIH HHS D43 TW008323Intramural NIH HHSNCI NIH HHS CA165923NCI NIH HHS R01 CA062006NCI NIH HHS R21 CA165923NICHD NIH HHS HD70324NICHD NIH HHS K02 HD070324
6 · The paper itself

Abstract

Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.

Indexed as

AgedBiomarkers, TumorCase-Control StudiesFemaleHumansJanus Kinase 1Lymphoma, Non-HodgkinMaleMiddle AgedPolymorphism, Single NucleotidePrognosisSTAT Transcription FactorsSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsBiomarkers, TumorJAK1 protein, humanJanus Kinase 1SOCS1 protein, humanSTAT Transcription FactorsSuppressor of Cytokine Signaling 1 ProteinSuppressor of Cytokine Signaling ProteinsCase–control studyJAK/STAT signaling pathwayNon-Hodgkin lymphomaPolymorphism

Identifiers

PMID23768868
PMCPMC3998836
OpenAlexW2147164764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.