ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2013
Continuous High Frequency Activity: a peculiar SEEG pattern related to specific brain regions.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed.
- Common Data Elements for Preclinical High-Frequency Oscillations in Epilepsy.Epilepsy currents · 2026Review
- Internal and external validation of comprehensive high-frequency activity biomarkers for epilepsy surgery.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery.medRxiv : the preprint server for health sciences · 2025Article
- Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Noninvasive classification of physiological and pathological high frequency oscillations in children.Brain communications · 2025Article
- The optimal montage to mark interictal epileptiform discharges and high-frequency oscillations in intraoperative electrocorticography.Clinical neurophysiology practice · 2025Article
- Pathological and Physiological High-frequency Oscillations on Electroencephalography in Patients with Epilepsy.Neuroscience bulletin · 2024Review
- Developmental atlas of phase-amplitude coupling between physiologic high-frequency oscillations and slow waves.Nature communications · 2023Article
- The neurophysiologic landscape of the sleep onset: a systematic review.Journal of thoracic disease · 2023Review
- Intracranial recordings in humans reveal specific hippocampal spectral and dorsal vs. ventral connectivity signatures during visual, attention and memory tasks.Scientific reports · 2022Article
- Refining epileptogenic high-frequency oscillations using deep learning: a reverse engineering approach.Brain communications · 2022Article
- Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones.Seizure · 2021Article
- Temporo-Frontal Coherences and High-Frequency iEEG Responses during Spatial Navigation in Patients with Drug-Resistant Epilepsy.Brain sciences · 2021Article
- Presurgical Evaluation of Epilepsy Using Resting-State MEG Functional Connectivity.Frontiers in human neuroscience · 2021Review
- Are HFOs in the Intra-operative ECoG Related to Hippocampal Sclerosis, Volume and IQ?Frontiers in neurology · 2021Article
- Identification of Epileptogenic and Non-epileptogenic High-Frequency Oscillations Using a Multi-Feature Convolutional Neural Network Model.Frontiers in neurology · 2021Article
- Are High Frequency Oscillations in Scalp EEG Related to Age?Frontiers in neurology · 2021Article
- Pitfalls in Scalp High-Frequency Oscillation Detection From Long-Term EEG Monitoring.Frontiers in neurology · 2020Article
- Stable high frequency background EEG activity distinguishes epileptic from healthy brain regions.Brain communications · 2020Article
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Abstract
objectiveWhile visually marking the high frequency oscillations in the stereo-EEG of epileptic patients, we observed a continuous/semicontinuous activity in the ripple band (80-250 Hz), which we defined continuous High Frequency Activity (HFA). We aim to analyze in all brain regions the occurrence and significance of this particular pattern.
methodsTwenty patients implanted in mesial temporal and neocortical areas were studied. One minute of slow-wave sleep was reviewed. The background was classified as continuous/semicontinuous, irregular, or sporadic based on the duration of the fast oscillations. Each channel was classified as inside/outside the seizure onset zone (SOZ) or a lesion.
resultsThe continuous/semicontinuous HFA occurred in 54 of the 790 channels analyzed, with a clearly higher prevalence in hippocampus and occipital lobe. No correlation was found with the SOZ or lesions. In the occipital lobe the continuous/semicontinuous HFA was present independently of whether eyes were open or closed.
conclusionsWe describe what appears to be a new physiological High Frequency Activity, independent of epileptogenicity, present almost exclusively in the hippocampus and occipital cortex but independent of the alpha rhythm. SIGNIFICANCE: The continuous HFA may be an intrinsic characteristic of specific brain regions, reflecting a particular type of physiological neuronal activity.
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