ArticleParasites & vectors2013
Susceptibility of Anopheles sinensis to Plasmodium vivax in malarial outbreak areas of central China.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Malaria outbreaks in China (1990-2013): a systematic review.Malaria journal · 2014Pooled it
- Development of a multiplex SNaPshot assay for simultaneous detection of multiple insecticide-resistance mutations in Anopheles sinensis.Parasites & vectors · 2026Article
- Real-time dynamic monitoring and multiplex PCR identification of vector mosquitoes in Zhejiang, China.PLoS neglected tropical diseases · 2025Article
- Analysis of Severe and Relapse Risks of Imported Malaria in Five Provinces of China.The American journal of tropical medicine and hygiene · 2025Article
- Revolutionizing Malaria Vector Control: The Importance of Accurate Species Identification through Enhanced Molecular Capacity.Microorganisms · 2023Review
- The malaria transmission in Anhui province China.Infectious Disease Modelling · 2023Article
- Transmission efficiency of Plasmodium vivax at low parasitaemia.Malaria journal · 2023Article
- Infectivity of symptomaticCurrent research in parasitology & vector-borne diseases · 2023Article
- Susceptibility of primary, secondary and suspected vectors to Plasmodium vivax and Plasmodium falciparum infection in Ethiopia.Parasites & vectors · 2022Article
- International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India.The American journal of tropical medicine and hygiene · 2022Article
- Evaluation of sustainable susceptibility to Plasmodium vivax infection among colonized Anopheles darlingi and Anopheles deaneorum.Malaria journal · 2022Article
- Vector control in China, from malaria endemic to elimination and challenges ahead.Infectious diseases of poverty · 2022Review
- The complete mitochondrial genome of major malaria vectorMitochondrial DNA. Part B, Resources · 2022Article
- Prevalence and molecular characterization of Wolbachia in field-collected Aedes albopictus, Anopheles sinensis, Armigeres subalbatus, Culex pipiens and Cx. tritaeniorhynchus in China.PLoS neglected tropical diseases · 2021Article
- Molecular phylogeny of the Anopheles hyrcanus group (Diptera: Culicidae) based on rDNA-ITS2 and mtDNA-COII.Parasites & vectors · 2021Article
- Optimization of the feeding rate of Anopheles farauti s.s. colony mosquitoes in direct membrane feeding assays.Parasites & vectors · 2021Article
- Multiplex PCR assay for the identification of eight Anopheles species belonging to the Hyrcanus, Barbirostris and Lindesayi groups.Malaria journal · 2021Article
- A natural symbiotic bacterium drives mosquito refractoriness to Plasmodium infection via secretion of an antimalarial lipase.Nature microbiology · 2021Article
- Species diversity and insecticide resistance within the Anopheles hyrcanus group in Ubon Ratchathani Province, Thailand.Parasites & vectors · 2020Article
- Comparison of infectivity of Plasmodium vivax to wild-caught and laboratory-adapted (colonized) Anopheles arabiensis mosquitoes in Ethiopia.Parasites & vectors · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnopheles sinensis, Anopheles anthropophagus, Anopheles minimus and Anopheles dirus are the major vectors of malaria transmission in China. Anopheles sinensis is considered a secondary vector due to its relatively low malaria-transmission ability. However, in 2005, an outbreak of over 40,000 Plasmodium vivax malaria cases was reported in areas where Anopheles sinensis was the only major vector. Therefore, it is necessary to reassess the malaria transmission ability of this vector species in China.
methodsLaboratory colonies of An. sinensis and An. anthropophagus, and first-generation progeny (F1) of An. sinensis that had been collected in central China, were infected by direct membrane feeding assay with mono-vivax gametocyte-containing blood collected from vivax-infected patients. The mosquitoes were kept for 7 to 14 days post-blood feeding to allow parasites to develop into oocysts and sporozoites. Infectivity was measured by dissecting midguts and salivary glands. The presence of oocysts and sporozoites was determined by microscopy at 7 and 14 days post-blood feeding, and the numbers of gametocytes and asexual parasites, as well as mosquito parasite infections, were determined.
resultsThe positive oocyst and sporozoite feed rates of the 142 pairs of lab-colony An. sinensis and An. anthropophagus were not significantly different, and the same results were found with the 10 pairs of laboratory and F1 An. sinensis. An. sinensis had more oocysts/midgut at 7 days post-feeding than An. anthropophagus, but the gametocytemia, asexual parasitemia, and ratio of macrogametocytes to microgametocytes, did not correlate with either oocyst or sporozoite infection. However, in the oocyst-positive mosquitoes, there was a correlation between gametocytemia and the average oocyst number/midgut.
conclusionsThe susceptibility of An. sinensis (both laboratory and F1) to P. vivax-infected blood is similar to Anopheles anthropophagus, when evaluated by membrane feeding assay under laboratory conditions. In recent years, in central China, the vivax malaria transmission ability of An. sinensis has probably been underestimated. Further studies of this species in other regions are needed. An. sinensis could also be a good candidate vector for evaluating candidate malaria transmission-blocking vaccines (TBV).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.