ArticleACS synthetic biology2013
Noise attenuation in the ON and OFF states of biological switches.
Article in ACS synthetic biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Emerging roles for integrated stress response signaling in homeostasis.The FEBS journal · 2025Review
- Double-edged role of resource competition in gene expression noise and control.Advanced genetics (Hoboken, N.J.) · 2022Article
- Multi-stability in cellular differentiation enabled by a network of three mutually repressing master regulators.Journal of the Royal Society, Interface · 2020Article
- Topology-dependent interference of synthetic gene circuit function by growth feedback.Nature chemical biology · 2020Article
- Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines.Biophysical journal · 2019Article
- Exploring intermediate cell states through the lens of single cells.Current opinion in systems biology · 2018Article
- Characterization of noise in multistable genetic circuits reveals ways to modulate heterogeneity.PloS one · 2018Article
- Beyond the Michaelis-Menten equation: Accurate and efficient estimation of enzyme kinetic parameters.Scientific reports · 2017Article
- Efficient and flexible implementation of Langevin simulation for gene burst production.Scientific reports · 2017Article
- A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions.BMC systems biology · 2017Article
- MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord.Nature communications · 2017Article
- Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst.PLoS computational biology · 2017Article
- Controlling Stochasticity in Epithelial-Mesenchymal Transition Through Multiple Intermediate Cellular States.Discrete and continuous dynamical systems. Series B · 2016Article
- Noise propagation with interlinked feed-forward pathways.Scientific reports · 2016Article
- Semi-adaptive response and noise attenuation in bone morphogenetic protein signalling.Journal of the Royal Society, Interface · 2015Article
- Promoter-mediated transcriptional dynamics.Biophysical journal · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
Biological switches must sense changes in signal concentration and at the same time buffer against signal noise. While many studies have focused on the response of switching systems to noise in the ON state, how systems buffer noise at both ON and OFF states is poorly understood. Through analytical and computational approaches, we find that switching systems require different dynamics at the OFF state than at the ON state in order to have good noise buffering capability. Specifically, we introduce a quantity called the input-associated Signed Activation Time (iSAT) that concisely captures an intrinsic temporal property at either the ON or OFF state. We discover a trade-off between achieving good noise buffering in the ON versus the OFF states: a large iSAT corresponds to noise amplification in the OFF state in contrast to noise buffering in the ON state. To search for biological circuits that can buffer noise in both ON and OFF states, we systematically analyze all three-node circuits and identify mutual activation as a central motif. We also study connections among signal sensitivity, iSAT, and noise amplification. We find that a large iSAT at the ON state maintains signaling sensitivity while minimizing noise propagation. Taken together, the analysis of iSATs helps reveal the noise properties of biological networks and should aid in the design of robust switches that can both repress noise at the OFF state and maintain a reliable ON state.
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