ArticleAnalytical chemistry2013
Phosphorescent nanosensors for in vivo tracking of histamine levels.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Emergency delivery of particulate drugs by active ejection using in vivo wireless devices.Nature biomedical engineering · 2026Article
- Coupling Organic Ultralong Lifetime Phosphorescence Materials with Paper-Based Bioanalytical Architectures for Autofluorescence-Free Sensing.ACS sensors · 2025Article
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Synthesis and Characterization of Polyethylene Glycol-Grafted Photoreactive Polyethylene Glycols for Antibiofouling Applications.Polymers · 2022Article
- Adipose Fin as a Natural "Optical Window" for Implantation of Fluorescent Sensors into Salmonid Fish.Animals : an open access journal from MDPI · 2022Article
- Real-Time,ACS sensors · 2022Review
- Article
- LipiSensors: Exploiting Lipid Nanoemulsions to Fabricate Ionophore-Based Nanosensors.Biosensors · 2020Article
- Luminescent Nanosensors for Ratiometric Monitoring of Three-Dimensional Oxygen Gradients in Laboratory and Clinical Pseudomonas aeruginosa Biofilms.Applied and environmental microbiology · 2019Article
- Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications.Chemical Society reviews · 2018Review
- In Vivo Biosensing: Progress and Perspectives.ACS sensors · 2017Article
- Microencapsulated fluorescent pH probe as implantable sensor for monitoring the physiological state of fish embryos.PloS one · 2017Article
- Remote in vivo stress assessment of aquatic animals with microencapsulated biomarkers for environmental monitoring.Scientific reports · 2016Article
- A Nanoporous Alumina Membrane Based Electrochemical Biosensor for Histamine Determination with Biofunctionalized Magnetic Nanoparticles Concentration and Signal Amplification.Sensors (Basel, Switzerland) · 2016Article
- Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms.International journal of molecular sciences · 2015Article
- Optical drug monitoring: photoacoustic imaging of nanosensors to monitor therapeutic lithium in vivo.ACS nano · 2015Article
- Glucose-sensitive nanofiber scaffolds with an improved sensing design for physiological conditions.The Analyst · 2015Article
- Implantable nanosensors: toward continuous physiologic monitoring.Analytical chemistry · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Continuously tracking bioanalytes in vivo will enable clinicians and researchers to profile normal physiology and monitor diseased states. Current in vivo monitoring system designs are limited by invasive implantation procedures and biofouling, limiting the utility of these tools for obtaining physiologic data. In this work, we demonstrate the first success in optically tracking histamine levels in vivo using a modular, injectable sensing platform based on diamine oxidase and a phosphorescent oxygen nanosensor. Our new approach increases the range of measurable analytes by combining an enzymatic recognition element with a reversible nanosensor capable of measuring the effects of enzymatic activity. We use these enzyme nanosensors (EnzNS) to monitor the in vivo histamine dynamics as the concentration rapidly increases and decreases due to administration and clearance. The EnzNS system measured kinetics that match those reported from ex vivo measurements. This work establishes a modular approach to in vivo nanosensor design for measuring a broad range of potential target analytes. Simply replacing the recognition enzyme, or both the enzyme and nanosensor, can produce a new sensor system capable of measuring a wide range of specific analytical targets in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.