ArticleOxidative medicine and cellular longevity2013
Major components of energy drinks (caffeine, taurine, and guarana) exert cytotoxic effects on human neuronal SH-SY5Y cells by decreasing reactive oxygen species production.
Article in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 94 citations in OpenAlex.
- Impact of maternal energy drink consumption during gestation and lactation on brain health in neonatal Wistar albino rats.Scientific reports · 2025Article
- The ameliorative effects of metformin and taurine against thioacetamide hepatotoxicity in rats.Toxicology research · 2025Article
- Guarana (Paullinia cupana) as a potential tool for mesenchymal stromal cells priming in regenerative medicine.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Energy drinks at adolescence: Awareness or unawareness?Frontiers in behavioral neuroscience · 2023Review
- Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana inNutrients · 2022Article
- Review
- Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway.Scientific reports · 2021Article
- Antioxidants, Food Processing and Health.Antioxidants (Basel, Switzerland) · 2021Article
- Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Effect of caffeinated energy drinks on the structure of hippocampal cornu ammonis 1 and dentate gyrus of adult male albino rats.Anatomy & cell biology · 2020Article
- Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and Neurons.Cells · 2019Article
- Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2019Article
- Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review.Nutrition and cancer · 2019Review
- Energy drinks and their component modulate attention, memory, and antioxidant defences in rats.European journal of nutrition · 2018Article
- Energy drink consumption: a survey in high school students and associated psychological effects.Journal of preventive medicine and hygiene · 2018Article
- Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites.PloS one · 2018Article
- Article
- Effect of Paullinia cupana Mart. Commercial Extract During the Aging of Middle Age Wistar Rats: Differential Effects on the Hippocampus and Striatum.Neurochemical research · 2017Article
- Glutamate‑mediated effects of caffeine and interferon‑γ on mercury-induced toxicity.International journal of molecular medicine · 2017Article
- Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
scopeTo elucidate the morphological and biochemical in vitro effects exerted by caffeine, taurine, and guarana, alone or in combination, since they are major components in energy drinks (EDs). METHODS AND
resultsOn human neuronal SH-SY5Y cells, caffeine (0.125-2 mg/mL), taurine (1-16 mg/mL), and guarana (3.125-50 mg/mL) showed concentration-dependent nonenzymatic antioxidant potential, decreased the basal levels of free radical generation, and reduced both superoxide dismutase (SOD) and catalase (CAT) activities, especially when combined together. However, guarana-treated cells developed signs of neurite degeneration in the form of swellings at various segments in a beaded or pearl chain-like appearance and fragmentation of such neurites at concentrations ranging from 12.5 to 50 mg/mL. Swellings, but not neuritic fragmentation, were detected when cells were treated with 0.5 mg/mL (or higher doses) of caffeine, concentrations that are present in EDs. Cells treated with guarana also showed qualitative signs of apoptosis, including membrane blebbing, cell shrinkage, and cleaved caspase-3 positivity. Flow cytometric analysis confirmed that cells treated with 12.5-50 mg/mL of guarana and its combinations with caffeine and/or taurine underwent apoptosis.
conclusionExcessive removal of intracellular reactive oxygen species, to nonphysiological levels (or "antioxidative stress"), could be a cause of in vitro toxicity induced by these drugs.
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