ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada
Duloxetine for the treatment of post-prostatectomy stress urinary incontinence.
Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- Comparative analysis of male stress urinary incontinence treatments: A review of efficacy, safety, and clinical outcomes.Current urology · 2026Review
- Pharmacotherapy in Stress Urinary Incontinence; A Literature Review.Current urology reports · 2024Review
- Latest Evidence on Post-Prostatectomy Urinary Incontinence.Journal of clinical medicine · 2023Review
- Article
- Priapism and renal colic in a patient treated with duloxetine.The mental health clinician · 2016Article
- Integrative review on the non-invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies.International journal of clinical practice · 2015Review
- A report of a regional service for post-prostatectomy urinary incontinence: a model for best practice?Therapeutic advances in urology · 2015Article
- [Conservative treatment in male urinary incontinence].Der Urologe. Ausg. A · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStress urinary incontinence (SUI) is a known complication following prostatectomy. Duloxetine, a combined serotonin/norepinephrine reuptake inhibitor, can decrease SUI by increasing urethral sphincter contractility. We examined the outcomes of patients with mild to moderate post-prostatectomy SUI treated with duloxetine.
methodsWe conducted a retrospective review of men treated with duloxetine to manage mild to moderate post-prostatectomy SUI from 2006 to 2012. All patients received oral duloxetine 30 mg once a week, then 60 mg thereafter. Patients were seen one month later to determine drug efficacy and side effects.
resultsIn total, 94 men were included in the study. Daily pad usage decreased from 2.9 (range: 1-5) to 1.6 (range: 0-4) (p < 0.05). Incontinence Impact Questionnaire (IIQ-7) scores decreased from 13.0 (range: 6-18) to 7.9 (range: 2-16) (p < 0.05). Linear satisfaction scores improved from 0.8 (range: 0-2) to 2.0 (range: 1-3) (p < 0.05). Following a 1-month duloxetine trial, 33/94 (35%) men reported satisfactory SUI improvement and requested to continue the medication. The drug was discontinued in 61/94 (65%) patients due to poor efficacy in 32/94 (34%), intolerable side effects in 14/94 (15%) or both in 15/94 (16%). Reported side effects included fatigue, light-headedness, insomnia, nausea and dry mouth.
conclusionsDuloxetine improved post-prostatectomy SUI in 47/94 (50%) men following a 1-month trial. However, only 33/94 (35%) patients were able to tolerate the drug. Duloxetine may be considered a treatment option for men with mild to moderate post-prostatectomy SUI.
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Registered trials
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