Trial reportInternational journal of chronic obstructive pulmonary disease2013
Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease.
Trial report in International journal of chronic obstructive pulmonary disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Reduced Chronic Obstructive Pulmonary Disease-Related Utilization of Health Care Services and Increased Social Activities by Patients Offered a 24/7 Accessible Telehealth Service Based on the Epital Care Model: Pragmatic Modified Stepped Wedge Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure.Annals of intensive care · 2026Article
- Predictive Value of CCQ and its Subdomains for Hospitalized Exacerbations in Chronic Obstructive Pulmonary Disease: A 3-Year Observational Prospective Study.Journal of general internal medicine · 2025Observational
- Lung Function After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer, Changes and Predictive Markers.Frontiers in oncology · 2021Article
- Functional respiratory imaging: heterogeneity of acute exacerbations of COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Management of severe acute exacerbations of COPD: an updated narrative review.Multidisciplinary respiratory medicine · 2018Review
- Development of the ProPal-COPD tool to identify patients with COPD for proactive palliative care.International journal of chronic obstructive pulmonary disease · 2017Article
- The chronic obstructive pulmonary disease assessment test improves the predictive value of previous exacerbations for poor outcomes in COPD.International journal of chronic obstructive pulmonary disease · 2015Observational
- A real-world evaluation of indacaterol and other bronchodilators in COPD: the INFLOW study.International journal of chronic obstructive pulmonary disease · 2015Observational
- Do females behave differently in COPD exacerbation?International journal of chronic obstructive pulmonary disease · 2015Article
- Health status measured by the Clinical COPD Questionnaire (CCQ) improves following post-acute pulmonary rehabilitation in patients with advanced COPD: a prospective observational study.NPJ primary care respiratory medicine · 2014Observational
- Course of COPD assessment test (CAT) and clinical COPD questionnaire (CCQ) scores during recovery from exacerbations of chronic obstructive pulmonary disease.Health and quality of life outcomes · 2013Article
- COPD management: role of symptom assessment in routine clinical practice.International journal of chronic obstructive pulmonary disease · 2013Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExacerbations of chronic obstructive pulmonary disease (COPD) are a major burden to patients and to society. Little is known about the possible role of day-to-day patient-reported outcomes during an exacerbation. This study aims to describe the day-to-day course of patient-reported health status during exacerbations of COPD and to assess its value in predicting clinical outcomes.
methodsData from two randomized controlled COPD exacerbation trials (n = 210 and n = 45 patients) were used to describe both the feasibility of daily collection of and the day-to-day course of patient-reported outcomes during outpatient treatment or admission to hospital. In addition to clinical parameters, the BORG dyspnea score, the Clinical COPD Questionnaire (CCQ), and the St George's Respiratory Questionnaire were used in Cox regression models to predict treatment failure, time to next exacerbation, and mortality in the hospital study.
resultsAll patient-reported outcomes showed a distinct pattern of improvement. In the multivariate models, absence of improvement in CCQ symptom score and impaired lung function were independent predictors of treatment failure. Health status and gender predicted time to next exacerbation. Five-year mortality was predicted by age, forced expiratory flow in one second % predicted, smoking status, and CCQ score. In outpatient management of exacerbations, health status was found to be less impaired than in hospitalized patients, while the rate and pattern of recovery was remarkably similar.
conclusionDaily health status measurements were found to predict treatment failure, which could help decision-making for patients hospitalized due to an exacerbation of COPD.
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