Trial reportHeart (British Cardiac Society)2013
The role of salt intake and salt sensitivity in the management of hypertension in South Asian people with chronic kidney disease: a randomised controlled trial.
Trial report in Heart (British Cardiac Society), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00702312 (A Multi-method Study of a Low-salt Dietary Approach to Control Blood Pressure in the Bangladeshi Chronic Kidney Disease Population.), which is not on this map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-method Study of a Low-salt Dietary Approach to Control Blood Pressure in the Bangladeshi Chronic Kidney Disease Population.
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Pooled it
- Effect of a low-salt diet on chronic kidney disease outcomes: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Guideline
- Altered dietary salt intake for people with chronic kidney disease.The Cochrane database of systematic reviews · 2021Pooled it
- Lifestyle behaviour change for preventing the progression of chronic kidney disease: a systematic review.BMJ open · 2019Pooled it
- Dietary Salt Restriction in Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials.Nutrients · 2018Pooled it
- Self-Monitoring and Self-Efficacy in Patients with Chronic Kidney Disease During Low-Sodium Diet Self-Management Interventions: Secondary Analysis of the ESMO and SUBLIME Trials.International journal of behavioral medicine · 2025Trial
- Effects of a low salt diet on isolated systolic hypertension: A community-based population study.Medicine · 2018Trial
- Effectiveness of culturally adapted lifestyle intervention package on blood pressure: A systematic review.Public health in practice (Oxford, England) · 2026Review
- Abnormal circadian pattern of urinary sodium excretion and chronic kidney disease progression.BMC nephrology · 2026Article
- Investigation of risk factors for osteoporosis with a focus on hypertension and estimation of the causal effect of hypertension on osteoporosis using causal forest.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Managing Hypertension in Chronic Kidney Disease: The Role of Diet and Guideline Recommendations.Journal of clinical medicine · 2025Review
- Sodium and water dynamics in the progression of chronic kidney disease: mechanisms and clinical significance.International urology and nephrology · 2024Review
- Analysis of impaired kidney function in the community around the Morosi nickel mines.Journal of public health in Africa · 2023Article
- Lifestyle Interventions, Kidney Disease Progression, and Quality of Life: A Systematic Review and Meta-analysis.Kidney medicine · 2023Article
- Psychometric testing of the Determinants of Salt-Restriction Behaviour Questionnaire in people of Chinese ancestry: a methodological study.BMC nursing · 2022Article
- Diet in the management of non-dialysis dependent chronic kidney disease: perceptions and practices of health professionals.BMC nephrology · 2022Article
- Dietary salt intake and its correlates among adults in a slum area in Dhaka, Bangladesh: a cross-sectional study.Nagoya journal of medical science · 2021Article
- Dietary intervention for the management of hypertension in Asia.Journal of clinical hypertension (Greenwich, Conn.) · 2021Review
- Epidemiology, baseline characteristics and risk of progression in the first South-Asian prospective longitudinal observational IgA nephropathy cohort.Kidney international reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effectiveness of salt restriction to lower blood pressure (BP) in Bangladeshi patients with chronic kidney disease (CKD) is uncertain.
objectiveTo test the hypothesis that a tailored intervention intended to reduce salt intake in addition to standard care will achieve a greater reduction in BP in UK Bangladeshi patients with CKD than standard care alone.
designA randomised parallel-group controlled trial conducted over a 6 month period.
settingA tertiary renal unit based in acute care hospital in East London.
participants56 adult participants of Bangladeshi origin with CKD and BP >130/80 mm Hg or on antihypertensive medication.
interventionParticipants were randomly allocated to receive a tailored low-salt diet or the standard low-salt advice. BP medication, physical activity and weight were monitored.
main outcome measuresThe primary outcome was change in ambulatory BP. Adherence to dietary advice was assessed by measurement of 24 h urinary salt excretion.
resultsOf 56 participants randomised, six withdrew at the start of the study. During the study, one intervention group participant died, one control group participant moved to Bangladesh. Data were available for the primary endpoint on 48 participants. Compared with control group the intervention urinary sodium excretion fell from 260 mmol/d to 103 mmol/d (-131 to -76, p<0.001) at 6 months and resulted in mean (95% CI) falls in 24 h systolic/diastolic BP of -8 mm Hg (-11 to -5)/2 (-4 to -2) both p<0.001.
conclusionsA tailored intervention can achieve moderate salt restriction in patients with CKD, resulting in clinically meaningful falls in BP independent of hypertensive medication.
trial registrationClinicalTrials.gov NCT00702312.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.