Evidence map›Paper›PMID 23765409›Full record

Trial reportEuropean journal of clinical pharmacology2013

Associations between generic substitution and patients' attitudes, beliefs and experiences.

Jette Rathe, Pia Larsen, Morten Andersen, Maja Paulsen, Dorte Jarbøl, Janus Thomsen, Jens Soendergaard

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Consumers' perception of generic substitution in Iran.International journal of clinical pharmacy · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jette RatheInstitute of Public Health, Research Unit of General Practice, University of Southern Denmark, Odense, Denmark, jrathe@health.sdu.dk.
Pia Larsen
Morten Andersen
Maja Paulsen
Dorte Jarbøl
Janus Thomsen
Jens Soendergaard

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGeneric substitution has been implemented in many countries, but knowledge about patients' attitudes, beliefs and experiences is still sparse.

aimTo assess associations between generic switching and patients' attitudes, beliefs and experiences with previous generic switching. DESIGN AND

settingA cross-sectional study comprising questionnaire responses from 2,476 randomly selected patients aged 20 years or older and living in the Region of Southern Denmark, who had redeemed substitutable drugs.

methodsThe questionnaire included items on beliefs about medicine, views on generic medicine and confidence in the healthcare system. Only prescriptions issued by the general practitioners were included. For each patient, we focused on one purchase of a generically substitutable drug (index drug). Patients were identified by means of a dispensing database.

resultsEarlier generic switches within the index ATC code were statistically significantly associated with experience of a generic switch (adjusted OR 5.93; 95 % CI 4.70-7.49). Having had more than five earlier switches within other ATC codes and having negative views on generic medicines reduced the odds of experiencing a generic switch. No associations were found between generic substitution and gender, drug group, number of different drugs used by the patient, confidence in the health care system and beliefs about medicine in general.

conclusionPatients who had once experienced a generic switch were more likely to accept a future generic switch within the same ATC code. Negative views on generic medicines were negatively associated with switching, while beliefs about medicine and confidence in the healthcare system had no influence.

Indexed as

Drug SubstitutionHealth Knowledge, Attitudes, PracticePatient Medication KnowledgeAdultAgedAnticonvulsantsAntidepressive AgentsCross-Sectional StudiesDatabases, PharmaceuticalDenmarkDrugs, GenericFemaleHumansMaleMiddle AgedPatient ComplianceAnticonvulsantsAntidepressive AgentsDrugs, Generic

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.