ArticleMolecular biology and evolution2013
The skeletal proteome of the coral Acropora millepora: the evolution of calcification by co-option and domain shuffling.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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86 citing papers in PubMed, 206 citations in OpenAlex.
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- Evolutionary rewiring of the endomesoderm gene regulatory networks specify skeleton secreting cells in stony corals.bioRxiv : the preprint server for biology · 2026Article
- Spatially resolved gene expression analysis illuminates location-specific functions in the reef-building coral Pocillopora acuta.PloS one · 2026Article
- Integrative analysis of coral plasticity and adaptations reveals key proteins driving resilience to changes in ocean carbonate chemistry.Marine life science & technology · 2025Article
- Electrostatic Collapse of Intrinsically Disordered Acid-Rich Protein Is Sensitive to Counterion Valency.The journal of physical chemistry letters · 2025Article
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- Comparative genomics of two closely related Acropora coral species with different spawning seasons reveals genomic regions possibly associated with gametogenesis.BMC ecology and evolution · 2025Article
- In-depth single-cell transcriptomic exploration of the regenerative dynamics in stony coral.Communications biology · 2025Article
- Proteomic analyses reveal the key role of gene co-option in the evolution of the scaly-foot snail scleritome.Communications biology · 2025Article
- Horizontal Transfer of msp130 Genes and the Evolution of Metazoan Biocalcification.Genome biology and evolution · 2025Article
- The molecular basis of octocoral calcification revealed by genome and skeletal proteome analyses.GigaScience · 2025Article
- Extreme Environmental Variability Induces Frontloading of Coral Biomineralisation Genes to Maintain Calcification Under pCOMolecular ecology · 2025Article
- Exploring proteins within the coccolith matrix.Scientific reports · 2024Article
- Diversification of von Willebrand Factor A and Chitin-Binding Domains in Pif/BMSPs Among Mollusks.Journal of molecular evolution · 2024Article
- Genome and tissue-specific transcriptomes of the large-polyp coral, Fimbriaphyllia (Euphyllia) ancora: a recipe for a coral polyp.Communications biology · 2024Article
- Genomic signatures suggesting adaptation to ocean acidification in a coral holobiont from volcanic COCommunications biology · 2023Article
- Synergistic and antagonistic interactions of oxybenzone and ocean acidification: new insight into vulnerable cellular processes in non-calcifying anthozoans.Frontiers in physiology · 2023Article
- Deep resilience: An evolutionary perspective on calcification in an age of ocean acidification.Frontiers in physiology · 2023Article
- Utilizing an artificial intelligence system to build the digital structural proteome of reef-building corals.GigaScience · 2022Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In corals, biocalcification is a major function that may be drastically affected by ocean acidification (OA). Scleractinian corals grow by building up aragonitic exoskeletons that provide support and protection for soft tissues. Although this process has been extensively studied, the molecular basis of biocalcification is poorly understood. Notably lacking is a comprehensive catalog of the skeleton-occluded proteins-the skeletal organic matrix proteins (SOMPs) that are thought to regulate the mineral deposition. Using a combination of proteomics and transcriptomics, we report the first survey of such proteins in the staghorn coral Acropora millepora. The organic matrix (OM) extracted from the coral skeleton was analyzed by mass spectrometry and bioinformatics, enabling the identification of 36 SOMPs. These results provide novel insights into the molecular basis of coral calcification and the macroevolution of metazoan calcifying systems, whereas establishing a platform for studying the impact of OA at molecular level. Besides secreted proteins, extracellular regions of transmembrane proteins are also present, suggesting a close control of aragonite deposition by the calicoblastic epithelium. In addition to the expected SOMPs (Asp/Glu-rich, galaxins), the skeletal repertoire included several proteins containing known extracellular matrix domains. From an evolutionary perspective, the number of coral-specific proteins is low, many SOMPs having counterparts in the noncalcifying cnidarians. Extending the comparison with the skeletal OM proteomes of other metazoans allowed the identification of a pool of functional domains shared between phyla. These data suggest that co-option and domain shuffling may be general mechanisms by which the trait of calcification has evolved.
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