ArticleJournal of cellular physiology2014
Chronic nicotine exposure systemically alters microRNA expression profiles during post-embryonic stages in Caenorhabditis elegans.
Article in Journal of cellular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Targeted Inhibition of P. gingivalis OMV-derived TsRNA by tetrahedral framework nucleic acids promotes periodontal regeneration.Journal of nanobiotechnology · 2026Article
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.Cardiovascular research · 2023Article
- The role of microRNAs in nicotine signaling.EXCLI journal · 2023Review
- The Regulatory Role of H19/miR-181a/ATG5 Signaling in Perinatal Nicotine Exposure-Induced Development of Neonatal Brain Hypoxic-Ischemic Sensitive Phenotype.International journal of molecular sciences · 2022Article
- Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring.American journal of physiology. Heart and circulatory physiology · 2020Article
- RNA and Oxidative Stress in Alzheimer's Disease: Focus on microRNAs.Oxidative medicine and cellular longevity · 2020Review
- Epigenetic down-regulation of BKInternational journal of cardiology · 2019Article
- Nicotine Modulates Growth Factors and MicroRNA to Promote Inflammatory and Fibrotic Processes.The Journal of pharmacology and experimental therapeutics · 2019Article
- Caenorhabditis elegans as an emerging model system in environmental epigenetics.Environmental and molecular mutagenesis · 2018Review
- MicroRNA Regulation of nAChR Expression and Nicotine-Dependent Behavior in C. elegans.Cell reports · 2017Article
- MicroRNA expression profiles during cotton (Gossypium hirsutum L) fiber early development.Scientific reports · 2017Article
- Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats.International journal of biological sciences · 2017Article
- Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Analysis of plasma microRNA expression profiles revealed different cancer susceptibility in healthy young adult smokers and middle-aged smokers.Oncotarget · 2016Article
- Identification and characterization of microRNAs in the plant parasitic root-knot nematode Meloidogyne incognita using deep sequencing.Functional & integrative genomics · 2016Article
- ChIP and Chips: Introducing the WormPharm for correlative studies employing pharmacology and genome-wide analyses inJournal of biological methods · 2016Article
- A C. elegans model of electronic cigarette use: Physiological effects of e-liquids in nematodes.BMC pharmacology & toxicology · 2015Article
- Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tobacco smoking is associated with many diseases. Addiction is of the most notorious tobacco-related syndrome and is mainly attributed to nicotine. In this study, we employed Caenorhabditis elegans as a biological model to systemically investigate the effect of chronic nicotine exposure on microRNA (miRNA) expression profile and their regulated biochemical pathways. Nicotine treatment (20 µM and 20 mM) was limited to the post-embryonic stage from L1 to L4 (∼31 h) period after which worms were collected for genome-wide miRNA profiling. Our results show that nicotine significantly altered the expression patterns of 40 miRNAs. The effect was proportional to the nicotine dose and was expected to have an additive, more robust response. Based on pathway enrichment analyses coupled with nicotine-induced miRNA patterns, we inferred that miRNAs as a system mediates "regulatory hormesis", manifested in biphasic behavioral and physiological phenotypes. We proposed a model where nicotine addiction is mediated by miRNAs' regulation of fos-1 and is maintained by epigenetic factors. Thus, our study offers new insights for a better understanding of the sensitivity of early developmental stages to nicotine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.