ReviewMolecules (Basel, Switzerland)2013
Natural 4-hydroxy-2,5-dimethyl-3(2H)-furanone (Furaneol®).
Review in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
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- Functional Characterization of Enone Oxidoreductase Orthologs Highlights Hidden Furaneol Biosynthetic Capacity in Apples.Journal of agricultural and food chemistry · 2026Article
- Exosome-niosome hybrid oxygen carrier for protection against acetaminophen-induced acute liver injury.Biomaterials science · 2026Article
- Unveiling the Role of Furanic Compounds in Coffee Quality.ACS omega · 2026Article
- Promiscuous Transferases Malonylate Furaneol Glucoside inJournal of agricultural and food chemistry · 2026Article
- From hive to laboratory - biotechnological potential of microorganisms from honey.World journal of microbiology & biotechnology · 2025Review
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- GC-MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Food science & nutrition · 2025Article
- Antibacterial efficacy and molecular docking analysis ofJournal of conservative dentistry and endodontics · 2025Article
- Article
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- Gamma Irradiation and Exogenous Proline Enhanced the Growth, 2AP Content, and Inhibitory Effects of Selected Bioactive Compounds against α-Glucosidase and α-Amylase in Thai Rice.Preventive nutrition and food science · 2024Article
- Urinary Biomarkers of Strawberry and Blueberry Intake.Metabolites · 2024Article
- Solid-State Fermented Pineapple Peel: A Novel Food Ingredient with Antioxidant and Anti-Inflammatory Properties.Foods (Basel, Switzerland) · 2023Article
- DNA methylation mediated by RdDM pathway and demethylation affects furanone accumulation through regulation ofHorticulture research · 2023Article
- Composition of Minerals and Volatile Organic Components of Non-Centrifugal Cane Sugars from Japan and ASEAN Countries.Foods (Basel, Switzerland) · 2023Article
- Effect of Frying Process on the Flavor Variations of Allium Plants.Foods (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
4-Hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF, furaneol®) and its methyl ether 2,5-dimethyl-4-methoxy-3(2H)-furanone (DMMF) are import aroma chemicals and are considered key flavor compounds in many fruit. Due to their attractive sensory properties they are highly appreciated by the food industry. In fruits 2,5-dimethyl-3(2H)-furanones are synthesized by a series of enzymatic steps whereas HDMF is also a product of the Maillard reaction. Numerous methods for the synthetic preparation of these compounds have been published and are applied by industry, but for the development of a biotechnological process the knowledge and availability of biosynthetic enzymes are required. During the last years substantial progress has been made in the elucidation of the biological pathway leading to HDMF and DMMF. This review summarizes the latest advances in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.