SynthesisCerebral cortex (New York, N.Y. : 1991)2014
Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies.
Synthesis in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 905 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms
The Effects of Short-term Lithium Administration on Striatal Reward Processing and Prefrontal Control During Reappraisal in Healthy Volunteers
High-level Construal as a Novel Pathway for Affect Regulation and Cancer Control
Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback
Who cites it
905 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The Human Dorsolateral Prefrontal Cortex in Pain and Pain Modulation: A Review and Activation-Likelihood Estimation Approach.European journal of pain (London, England) · 2026Pooled it
- Pooled it
- Fears Worth Testing Out: A Systematic Review of the Neural Mechanisms of Treatment Outcome for Anxiety-Related Disorders.Current topics in behavioral neurosciences · 2025Pooled it
- Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis.Schizophrenia research · 2024Pooled it
- Cognitive reappraisal of food craving and emotions: a coordinate-based meta-analysis of fMRI studies.Social cognitive and affective neuroscience · 2024Pooled it
- Neural mechanisms of different types of envy: a meta-analysis of activation likelihood estimation methods for brain imaging.Frontiers in psychology · 2024Pooled it
- Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy.Annals of neurology · 2026Trial
- Effect of app-based mindfulness on extinction recall - a 7T-fMRI study.Scientific reports · 2026Trial
- Effectiveness of transcranial direct current stimulation on emotional instability and impulsivity in atypical depression and bipolar II disorder.Scientific reports · 2025Trial
- Effects of transcranial direct current stimulation of the right dorsolateral prefrontal cortex on craving and negative emotion regulation in individuals at risk for problematic pornography use: A double-blind, placebo-controlled study.Journal of behavioral addictions · 2025Trial
- Effects of a group-based compassion microintervention compared to cognitive reappraisal training on cardiovascular, self-reported, and behavioral stress reactivity among young adults: A cluster randomized controlled trial.Applied psychology. Health and well-being · 2025Trial
- Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention.Psychiatry research. Neuroimaging · 2024Trial
- Amygdala Reactivity, Antidepressant Discontinuation, and Relapse.JAMA psychiatry · 2024Trial
- Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.Psychopharmacology · 2024Trial
- Metabolic and microstructural brain alterations associated with occupational blast exposure.Neuroimage. Reports · 2026Article
- Neurocognitive Mechanisms of Preventive Cognitive Therapy as Relapse Prevention in Remitted Major Depressive Disorder: A Randomized Controlled Trial.Biological psychiatry global open science · 2026Article
- Comparative Efficacy of Non-invasive Brain Stimulation for Pain, Anxiety, and Depression: A Systematic Review and Network Meta-analysis.Pain and therapy · 2026Review
- Distinct oscillatory signatures of emotional reactivity and cognitive reappraisal revealed through multiclass EEG decoding.Cognitive, affective & behavioral neuroscience · 2026Article
- Functional Magnetic Resonance Imaging Correlates of Cognitive Reappraisal of Negative Emotion: A Brain Activation and Generalized Psychophysiological Interaction Study.Brain and behavior · 2026Article
- Peer-guided movie neurofeedback to facilitate recovery in opioid use disorder.medRxiv : the preprint server for health sciences · 2026Article
845 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In recent years, an explosion of neuroimaging studies has examined cognitive reappraisal, an emotion regulation strategy that involves changing the way one thinks about a stimulus in order to change its affective impact. Existing models broadly agree that reappraisal recruits frontal and parietal control regions to modulate emotional responding in the amygdala, but they offer competing visions of how this is accomplished. One view holds that control regions engage ventromedial prefrontal cortex (vmPFC), an area associated with fear extinction, that in turn modulates amygdala responses. An alternative view is that control regions modulate semantic representations in lateral temporal cortex that indirectly influence emotion-related responses in the amygdala. Furthermore, while previous work has emphasized the amygdala, whether reappraisal influences other regions implicated in emotional responding remains unknown. To resolve these questions, we performed a meta-analysis of 48 neuroimaging studies of reappraisal, most involving downregulation of negative affect. Reappraisal consistently 1) activated cognitive control regions and lateral temporal cortex, but not vmPFC, and 2) modulated the bilateral amygdala, but no other brain regions. This suggests that reappraisal involves the use of cognitive control to modulate semantic representations of an emotional stimulus, and these altered representations in turn attenuate activity in the amygdala.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.