ArticleAging2013
Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila.
Article in Aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 84 citations in OpenAlex.
- Convergent evolution of H4K16ac-mediated dosage compensation in the ZW species Artemia franciscana.PLoS genetics · 2025Article
- Sex-Specific Lifespan Extension and Anti-Obesogenic Effects ofNutrients · 2025Article
- Regulatory Roles for SIRT1 in Aging and Immunosenescence.Results and problems in cell differentiation · 2025Review
- Radiation Hormesis to Improve the Quality of AdultInsects · 2022Article
- An aqueous extract of the brown algaAging · 2022Article
- Genomic architecture and functional unit of mimicry supergene in female limited Batesian mimicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
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- Alterations in biogenic amines levels associated with age-related muscular tissue impairment inSaudi journal of biological sciences · 2022Article
- Genes and Longevity of Lifespan.International journal of molecular sciences · 2022Review
- Hemocytes and fat body cells, the only professional immune cell types inFrontiers in immunology · 2022Article
- Article
- Review
- Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.Developmental biology · 2021Review
- Origin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease.Frontiers in cell and developmental biology · 2021Review
- Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?Developmental cell · 2020Review
- Impact of Probiotic Combination inMicroorganisms · 2020Article
- A high-fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine.PLoS genetics · 2020Article
- Furbellow (Brown Algae) Extract Increases Lifespan inNutrients · 2020Article
- The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan inFrontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sir2 is the most intensively discussed longevity gene in current aging research. Although, the gene encoding a NAD(+)-dependent histone deacetylase initially was found to extend lifespan of various organisms ranging from yeast to mammals, serious doubts regarding its role in longevity have been expressed recently. In this study, we tested whether tissue-specific overexpression of Sir2 in the adult fat body can extend lifespan when compared to genetically identical controls. We also wanted to elucidate the mechanisms by which fat body Sir2 promotes longevity by studying the phenotypic and transcriptional changes in the fat body. We found that moderate (3-fold) Sir2 overexpression in the fat body during adulthood only can promote longevity in both sexes by roughly 13 %. In addition, we obtained transcriptional profiles elicited by this overexpression and propose a role for Sir2 in lipid droplet biology especially under conditions of starvation. Furthermore, our data do not support the idea of Sir2 mediating the response to dietary restriction (DR) because transcriptional profiles of fat bodies after DR or Sir2 overexpression do not match. This study provides additional independent evidence for the concept of Sir2 as a longevity gene and as a promising pharmacological target to cure age-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.