ReviewEnvironmental science and pollution research international2015
Assessing the bioavailability and bioaccessibility of metals and metalloids.
Review in Environmental science and pollution research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Molecular and Cellular Mechanisms of Plant Responses to Heavy Metal Stress in Mining-Impacted Environments.Plants (Basel, Switzerland) · 2026Review
- Article
- In Vitro Bioaccessibility and Speciation of Toxic and Nutritional Trace Elements in Brazil Nuts.International journal of molecular sciences · 2025Article
- A Multidisciplinary Approach That Considers Occurrence, Geochemistry, Bioavailability, and Toxicity to Prioritize Critical Minerals for Environmental Research.Environmental science & technology · 2024Article
- Bioaccessibility of lead and cadmium in soils around typical lead-acid power plants and their effect on gut microorganisms.Environmental geochemistry and health · 2024Article
- In Vitro Assessment of the Physiologically Relevant Oral Bioaccessibility of Metallic Elements in Edible Herbs Using the Unified Bioaccessibility Protocol.Molecules (Basel, Switzerland) · 2023Article
- Article
- Effect of Polishing on Lead and Cadmium Bioavailability in Rice and Its Health Implications.Foods (Basel, Switzerland) · 2022Article
- Bioaccessibility and human exposure to metals in urban soils (Huelva, SW Spain): evaluation by in vitro gastric extraction.Environmental geochemistry and health · 2022Article
- Navigating a Two-Way Street: Metal Toxicity and the Human Gut Microbiome.Environmental health perspectives · 2022Article
- Arsenic and lead in soil: impacts on element mobility and bioaccessibility.Environmental geochemistry and health · 2022Article
- Plumbojarosite Remediation of Soil Affects Lead Speciation and Elemental Interactions in Soil and in Mice Tissues.Environmental science & technology · 2021Article
- Predicting the relative oral bioavailability of naturally occurring As, Cd and Pb from in vitro bioaccessibility measurement: implications for human soil ingestion exposure assessment.Environmental geochemistry and health · 2021Article
- Chronic kidney disease of unknown aetiology in Sri Lanka and the exposure to environmental chemicals: a review of literature.Environmental geochemistry and health · 2019Review
- Chemical fractionation of heavy metals in fine particulate matter and their health risk assessment through inhalation exposure pathway.Environmental geochemistry and health · 2019Article
- Human Health Risk and Bioaccessibility of Toxic Metals in Topsoils from Gbani Mining Community in Ghana.Journal of health & pollution · 2019Article
- Characterization, Spatial Variation and Risk Assessment of Heavy Metals and a Metalloid in Surface Soils in Obuasi, Ghana.Journal of health & pollution · 2018Article
- In vitro inhalation/ingestion bioaccessibility, health risks, and source appointment of airborne particle-bound elements trapped in room air conditioner filters.Environmental science and pollution research international · 2018Article
- Is Unpaved Road Dust Near Fairbanks, Alaska a Health Concern? Examination of the Total and Bioaccessible Metal(loid)s.Journal of young investigators · 2017Article
- Distribution and bioaccessibility of metals in urban soils of Kumasi, Ghana.Environmental monitoring and assessment · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioavailability (BA) determines the potential harm of a contaminant that exerts on the receptor. However, environmental guidelines for site contamination assessment are often set assuming the contaminant is 100 % bioavailable. This conservative approach to assessing site risk may result in the unnecessary and expensive remediation of a contaminated site. The National Environmental Protection Measures in Australia has undergone a statutory 5-year review that recommended that contaminant bioavailability and bioaccessibility (BAC) measures be adopted as part of the contaminated site risk assessment process by the National Environment Protection Council. We undertook a critical review of the current bioavailability and bioaccessibility approaches, methods and their respective limitations. The 'gold' standard to estimate the portion of a contaminant that reaches the system circulatory system (BA) of its receptor is to determine BA in an in vivo system. Various animal models have been utilised for this purpose. Because of animal ethics issues, and the expenses associated with performing in vivo studies, several in vitro methods have been developed to determine BAC as a surrogate model for the estimation of BA. However, few in vitro BAC studies have been calibrated against a reliable animal model, such as immature swine. In this review, we have identified suitable methods for assessing arsenic and lead BAC and proposed a decision tree for the determination of contaminant bioavailability and bioaccessibility for health risk assessment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.