ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Glucagon-like peptide-2 induces rapid digestive adaptation following intestinal resection in preterm neonates.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Farnesoid X Receptor Agonist Tropifexor Improves Intestinal Defense Response and Epithelial Barrier Function in Neonatal Piglets Receiving Parenteral Nutrition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Parenteral Nutrition, Inflammatory Bowel Disease, and Gut Barrier: An Intricate Plot.Nutrients · 2024Review
- Absorption of an engineered medium-chain fatty acid analogue in two short bowel syndrome minipig models.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- Supplementation with artificial sweetener and capsaicin alters metabolic flexibility and performance in heat-stressed and feed-restricted pigs.Journal of animal science · 2022Article
- Outcomes and Perioperative Nutritional Management in a Porcine Model of Short Bowel Syndrome.The Journal of surgical research · 2022Article
- Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction.The Journal of infectious diseases · 2021Review
- Establishment of porcine and monkey colonic organoids for drug toxicity study.Cell regeneration (London, England) · 2021Article
- Review
- Nutritional and pharmacological strategy in children with short bowel syndrome.Pediatric surgery international · 2021Review
- Dietary supplementation of artificial sweetener and capsicum oleoresin as a strategy to mitigate the negative consequences of heat stress on pig performance.Journal of animal science · 2020Article
- Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Host-Gut Microbiota Crosstalk in Intestinal Adaptation.Cellular and molecular gastroenterology and hepatology · 2018Review
- Prolonged Absence of Mechanoluminal Stimulation in Human Intestine Alters the Transcriptome and Intestinal Stem Cell Niche.Cellular and molecular gastroenterology and hepatology · 2017Article
- Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis.Seminars in perinatology · 2017Review
- Large Animal Models: The Key to Translational Discovery in Digestive Disease Research.Cellular and molecular gastroenterology and hepatology · 2016Article
- Generation of glucagon-like peptide-2-expressing Saccharomyces cerevisiae and its improvement of the intestinal health of weaned rats.Microbial biotechnology · 2016Article
- GLP-2 Prevents Intestinal Mucosal Atrophy and Improves Tissue Antioxidant Capacity in a Mouse Model of Total Parenteral Nutrition.Nutrients · 2016Article
- Porcine models of digestive disease: the future of large animal translational research.Translational research : the journal of laboratory and clinical medicine · 2015Review
- Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: translational relevance and challenges.American journal of physiology. Gastrointestinal and liver physiology · 2014Review
- Invited review: the preterm pig as a model in pediatric gastroenterology.Journal of animal science · 2013Review
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
Short bowel syndrome (SBS) is a frequent complication after intestinal resection in infants suffering from intestinal disease. We tested whether treatment with the intestinotrophic hormone glucagon-like peptide-2 (GLP-2) increases intestinal volume and function in the period immediately following intestinal resection in preterm pigs. Preterm pigs were fed enterally for 48 h before undergoing resection of 50% of the small intestine and establishment of a jejunostomy. Following resection, pigs were maintained on total parenteral nutrition (TPN) without (SBS, n = 8) or with GLP-2 treatment (3.5 μg/kg body wt per h, SBS+GLP-2, n = 7) and compared with a group of unresected preterm pigs (control, n = 5). After 5 days of TPN, all piglets were fed enterally for 24 h, and a nutrient balance study was performed. Intestinal resection was associated with markedly reduced endogenous GLP-2 levels. GLP-2 increased the relative absorption of wet weight (46 vs. 22%), energy (79 vs. 64%), and all macronutrients (all parameters P < 0.05). These findings were supported by a 200% increase in sucrase and maltase activities, a 50% increase in small intestinal epithelial volume (P < 0.05), as well as increased DNA and protein contents and increased total protein synthesis rate in SBS+GLP-2 vs. SBS pigs (+100%, P < 0.05). Following intestinal resection in preterm pigs, GLP-2 induced structural and functional adaptation, resulting in a higher relative absorption of fluid and macronutrients. GLP-2 treatment may be a promising therapy to enhance intestinal adaptation and improve digestive function in preterm infants with jejunostomy following intestinal resection.
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