ArticleCell death & disease2013
Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Annexin A1 triggers autophagy to orchestrate radioiodine resistance in thyroid cancer via upregulating HMGB1.Cancer cell international · 2026Article
- The interplay between DNA damage response and mitochondrial dysfunction in radiotherapy.Frontiers in oncology · 2025Review
- Targeting Radiation Resistance in Oesophageal Adenocarcinoma with Pyrazinib-Functionalised Gold Nanoparticles.Cancers · 2024Article
- The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Role of p53 in Regulating Radiation Responses.Life (Basel, Switzerland) · 2022Review
- Metabolic response to radiation therapy in cancer.Molecular carcinogenesis · 2022Review
- Review
- DNA damage invokes mitophagy through a pathway involving Spata18.Nucleic acids research · 2020Article
- Review
- B7-H3 increases the radioresistance of gastric cancer cells through regulating baseline levels of cell autophagy.American journal of translational research · 2019Article
- Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition.Scientific reports · 2018Article
- PGC1α: Friend or Foe in Cancer?Genes · 2018Review
- Profiles of Radioresistance Mechanisms in Prostate Cancer.Critical reviews in oncogenesis · 2018Review
- Article
- Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?EBioMedicine · 2017Review
- Radiation induces progenitor cell death, microglia activation, and blood-brain barrier damage in the juvenile rat cerebellum.Scientific reports · 2017Article
- Radiation-induced translational control of gene expression.Translation (Austin, Tex.) · 2017Review
- Polysome Profiling Links Translational Control to the Radioresponse of Glioblastoma Stem-like Cells.Cancer research · 2016Article
- Role of Redox Status in Development of Glioblastoma.Frontiers in immunology · 2016Review
- Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells.Cellular and molecular bioengineering · 2015Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial biogenesis is an orchestrated process that presides to the regulation of the organelles homeostasis within a cell. We show that γ-rays, at doses commonly used in the radiation therapy for cancer treatment, induce an increase in mitochondrial mass and function, in response to a genotoxic stress that pushes cells into senescence, in the presence of a functional p53. Although the main effector of the response to γ-rays is the p53-p21 axis, we demonstrated that mitochondrial biogenesis is only indirectly regulated by p53, whose activation triggers a murine double minute 2 (MDM2)-mediated hypoxia-inducible factor 1α (HIF1α) degradation, leading to the release of peroxisome-proliferator activated receptor gamma co-activator 1β inhibition by HIF1α, thus promoting mitochondrial biogenesis. Mimicking hypoxia by HIF1α stabilization, in fact, blunts the mitochondrial response to γ-rays as well as the induction of p21-mediated cell senescence, indicating prevalence of the hypoxic over the genotoxic response. Finally, we also show in vivo that post-radiotherapy mitochondrial DNA copy number increase well correlates with lack of HIF1α increase in the tissue, concluding this may be a useful molecular tool to infer the trigger of a hypoxic response during radiotherapy, which may lead to failure of activation of cell senescence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.