ArticleJournal of inorganic biochemistry2013
Selective accumulation of aluminum in cerebral arteries in Alzheimer's disease (AD).
Article in Journal of inorganic biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Dietary Aluminium Exposure and Human Health: Sources, Bioavailability, Toxicokinetics, and Health Risk Assessment.Nutrients · 2026Review
- Bioinorganic Chemistry of Micronutrients Related to Alzheimer's and Parkinson's Diseases.Molecules (Basel, Switzerland) · 2023Review
- Aluminium in the Human Brain: Routes of Penetration, Toxicity, and Resulting Complications.International journal of molecular sciences · 2023Review
- Cognitive impairment of workers in a large-scale aluminium factory in China: a cross-sectional study.BMJ open · 2019Article
- Aluminum in Neurological and Neurodegenerative Disease.Molecular neurobiology · 2019Article
- Aluminum in neurological disease - a 36 year multicenter study.Journal of Alzheimer's disease & Parkinsonism · 2019Article
- Identification of the Al-binding proteins that account for aluminum neurotoxicity and transportToxicology research · 2018Article
- Water Quality and Brain Function.International journal of environmental research and public health · 2017Review
- The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics?International journal of environmental research and public health · 2017Review
- Effect of PGEOncotarget · 2017Article
- Clinical effects of chemical exposures on mitochondrial function.Toxicology · 2017Review
- The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?Metabolic brain disease · 2017Review
- The Health Effects of Aluminum Exposure.Deutsches Arzteblatt international · 2017Review
- Aluminum Exposure at Human Dietary Levels for 60 Days Reaches a Threshold Sufficient to Promote Memory Impairment in Rats.Neurotoxicity research · 2017Article
- Systemic Inflammation in C57BL/6J Mice Receiving Dietary Aluminum Sulfate; Up-Regulation of the Pro-Inflammatory Cytokines IL-6 and TNFα, C-Reactive Protein (CRP) and miRNA-146a in Blood Serum.Journal of Alzheimer's disease & Parkinsonism · 2017Article
- Toxin-Induced Experimental Models of Learning and Memory Impairment.International journal of molecular sciences · 2016Review
- Pioglitazone Ameliorates Neuron Loss in the Cortex after Aluminum-Treatment in Rats.Neurology research international · 2015Article
- Aluminum and its potential contribution to Alzheimer's disease (AD).Frontiers in aging neuroscience · 2014Article
- The mobilization of aluminum into the biosphere.Frontiers in neurology · 2014Review
- Impact of plasma aluminum on neurocognitive outcomes at early school age in children with intestinal failure.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Once biologically available aluminum bypasses gastrointestinal and blood-brain barriers, this environmentally-abundant neurotoxin has an exceedingly high affinity for the large pyramidal neurons of the human brain hippocampus. This same anatomical region of the brain is also targeted by the earliest evidence of Alzheimer's disease (AD) neuropathology. The mechanism for the selective targeting and transport of aluminum into the hippocampus of the human brain is not well understood. In an effort to improve our understanding of a pathological aluminum entry system into the brain, this study examined the aluminum content of 8 arteries that supply blood to the hippocampus, including the aorta and several cerebral arteries. In contrast to age-matched controls, in AD patients we found a gradient of increasing aluminum concentration from the aorta to the posterior cerebral artery that supplies blood to the hippocampus. Primary cultures of human brain endothelial cells were found to have an extremely high affinity for aluminum when compared to other types of brain cells. Together, these results suggest for the first time that endothelial cells that line the cerebral vasculature may have biochemical attributes conducive to binding and targeting aluminum to selective anatomical regions of the brain, such as the hippocampus, with potential downstream pro-inflammatory and pathogenic consequences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.