Trial reportAJNR. American journal of neuroradiology
Optimized T1-MPRAGE sequence for better visualization of spinal cord multiple sclerosis lesions at 3T.
Trial report in AJNR. American journal of neuroradiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Expert Panel Consensus Guidelines of the German Society of Neuroradiology on the Use of Magnetic Resonance Imaging in the Diagnosis and Monitoring of Multiple Sclerosis.Clinical neuroradiology · 2026Guideline
- Spinal cord imaging in multiple sclerosis: from diagnosis to disease progression.Journal of neurology · 2026Review
- Differential Assessment of Internal Jugular Vein Stenosis in Patients Undergoing CT and MRI with Contrast.Tomography (Ann Arbor, Mich.) · 2024Article
- Assessing the Equivalence of Brain-Derived Measures from Two 3D T1-Weighted Acquisitions: One Covering the Brain and One Covering the Brain and Spinal Cord.AJNR. American journal of neuroradiology · 2023Article
- Optimized three-dimensional ultrashort echo time: Magnetic resonance fingerprinting for myelin tissue fraction mapping.Human brain mapping · 2023Article
- Phantom Study on the Robustness of MR Radiomics Features: Comparing the Applicability of 3D Printed and Biological Phantoms.Diagnostics (Basel, Switzerland) · 2022Article
- [New MRI guidelines for multiple sclerosis].Der Radiologe · 2022Review
- Pre-contrast T1-weighted imaging of the spinal cord may be unnecessary in patients with multiple sclerosis.European radiology · 2021Article
- Does T2 inversion aid in identifying disc pathologies?Journal of clinical orthopaedics and trauma · 2021Article
- Detection of multiple sclerosis lesions in the cervical cord: which of the MAGNIMS 'mandatory' non-gadolinium enhanced sagittal sequences is optimal at 3T?The neuroradiology journal · 2021Article
- MRI of the Entire Spinal Cord-Worth the While or Waste of Time? A Retrospective Study of 74 Patients with Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Imaging of the Spinal Cord in Multiple Sclerosis: Past, Present, Future.Brain sciences · 2020Review
- Spinal Cord Involvement in MS and Other Demyelinating Diseases.Biomedicines · 2020Review
- 3D PSIR MRI at 3 Tesla improves detection of spinal cord lesions in multiple sclerosis.Journal of neurology · 2020Article
- Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.Brain : a journal of neurology · 2019Review
- The Central Vein Sign in Radiologically Isolated Syndrome.AJNR. American journal of neuroradiology · 2019Article
- Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.Brain : a journal of neurology · 2019Article
- A 3T Phase-Sensitive Inversion Recovery MRI Sequence Improves Detection of Cervical Spinal Cord Lesions and Shows Active Lesions in Patients with Multiple Sclerosis.AJNR. American journal of neuroradiology · 2019Article
- Advances in spinal cord imaging in multiple sclerosis.Therapeutic advances in neurological disorders · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
background and purposeSpinal cord lesions are highly prevalent in MS, and their visualization can help both in diagnosis and patient follow-up. However, the sensitivity of MR imaging to spinal cord lesions remains poor, primarily because of suboptimal contrast between lesions and a normal-appearing cord. Here, we propose an optimized 3D MPRAGE sequence for improved detection of MS lesions in the spinal cord at 3T. MATERIALS AND
methodsImages were acquired by use of T2 FSE, STIR, T1-gradient recalled-echo (for T1 mapping), and T1-MPRAGE in the sagittal plane, and T2*-weighted scans in the axial plane, on 40 patients with MS and 7 healthy volunteers. Two observers qualitatively evaluated the images for lesion conspicuity. Lesions seen between the C1 and C4 segments in 10 randomly selected patients with MS were further evaluated quantitatively for contrast-to-noise ratio between the lesion and normal-appearing cord, and for lesion burden.
resultsSpinal cord lesions were more conspicuous on the optimized T1-MPRAGE sequence than on any other sequence tested. Detailed analysis revealed that lesions were almost 3 times more conspicuous (P < .01), and the total lesion volume was 2 times greater (P < .05, n=10), in the T1-MPRAGE sequence compared with the standard STIR sequence. Correlation of clinical disability (Expanded Disability Status Score) with lesion load from each sequence also demonstrated the importance of the improved lesion conspicuity with T1-MPRAGE.
conclusionsThe optimized T1-MPRAGE sequence described here improves the reliability of lesion visualization and estimation of lesion burden, especially when used in conjunction with other well-established clinical sequences.
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